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Krüppel cripples prostate cancer: KLF6 progress and prospects.
Narla G, Friedman SL, Martignetti JA. Narla G, et al. Among authors: martignetti ja. Am J Pathol. 2003 Apr;162(4):1047-52. doi: 10.1016/S0002-9440(10)63901-6. Am J Pathol. 2003. PMID: 12651597 Free PMC article. Review. No abstract available.
A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.
Narla G, Difeo A, Reeves HL, Schaid DJ, Hirshfeld J, Hod E, Katz A, Isaacs WB, Hebbring S, Komiya A, McDonnell SK, Wiley KE, Jacobsen SJ, Isaacs SD, Walsh PC, Zheng SL, Chang BL, Friedrichsen DM, Stanford JL, Ostrander EA, Chinnaiyan AM, Rubin MA, Xu J, Thibodeau SN, Friedman SL, Martignetti JA. Narla G, et al. Among authors: martignetti ja. Cancer Res. 2005 Feb 15;65(4):1213-22. doi: 10.1158/0008-5472.CAN-04-4249. Cancer Res. 2005. PMID: 15735005
Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.
Kremer-Tal S, Narla G, Chen Y, Hod E, DiFeo A, Yea S, Lee JS, Schwartz M, Thung SN, Fiel IM, Banck M, Zimran E, Thorgeirsson SS, Mazzaferro V, Bruix J, Martignetti JA, Llovet JM, Friedman SL. Kremer-Tal S, et al. Among authors: martignetti ja. J Hepatol. 2007 Apr;46(4):645-54. doi: 10.1016/j.jhep.2006.10.012. Epub 2006 Nov 27. J Hepatol. 2007. PMID: 17196295 Free PMC article.
141 results