Dubowchik GM - Search Results

1

Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure.

Degnan AP, Chaturvedula PV, Conway CM, Cook DA, Davis CD, Denton R, Han X, Macci R, Mathias NR, Moench P, Pin SS, Ren SX, Schartman R, Signor LJ, Thalody G, Widmann KA, Xu C, Macor JE, Dubowchik GM. Degnan AP, et al. Among authors: dubowchik gm. J Med Chem. 2008 Aug 28;51(16):4858-61. doi: 10.1021/jm800546t. Epub 2008 Jul 30. J Med Chem. 2008. PMID: 18665579

2

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin.

Dubowchik GM, Firestone RA. Dubowchik GM, et al. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3341-6. doi: 10.1016/s0960-894x(98)00609-x. Bioorg Med Chem Lett. 1998. PMID: 9873731

3

Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: inhibition of aggregation by methoxytriethyleneglycol chains.

King HD, Dubowchik GM, Mastalerz H, Willner D, Hofstead SJ, Firestone RA, Lasch SJ, Trail PA. King HD, et al. Among authors: dubowchik gm. J Med Chem. 2002 Sep 12;45(19):4336-43. doi: 10.1021/jm020149g. J Med Chem. 2002. PMID: 12213074

4

2-arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy.

Dubowchik GM, Michne JA, Zuev D, Schwartz W, Scola PM, James CA, Ruediger EH, Pin SS, Burris KD, Balanda LA, Gao Q, Wu D, Fung L, Fiedler T, Browman KE, Taber MT, Zhang J. Dubowchik GM, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3997-4000. doi: 10.1016/j.bmcl.2003.08.055. Bioorg Med Chem Lett. 2003. PMID: 14592493

5

Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists.

Karageorge GN, Bertenshaw S, Iben L, Xu C, Sarbin N, Gentile A, Dubowchik GM. Karageorge GN, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5881-4. doi: 10.1016/j.bmcl.2004.09.024. Bioorg Med Chem Lett. 2004. PMID: 15501061

6

Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis.

Zuev D, Michne JA, Pin SS, Zhang J, Taber MT, Dubowchik GM. Zuev D, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2005 Jan 17;15(2):431-4. doi: 10.1016/j.bmcl.2004.10.055. Bioorg Med Chem Lett. 2005. PMID: 15603967

7

Stereoselective synthesis of new conformationally restricted analogues of a potent CGRP receptor antagonist.

Zuev D, Michne JA, Huang H, Beno BR, Wu D, Gao Q, Torrente JR, Xu C, Conway CM, Macor JE, Dubowchik GM. Zuev D, et al. Among authors: dubowchik gm. Org Lett. 2005 Jun 9;7(12):2465-8. doi: 10.1021/ol0510062. Org Lett. 2005. PMID: 15932224

8

Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists.

Han X, Pin SS, Burris K, Fung LK, Huang S, Taber MT, Zhang J, Dubowchik GM. Han X, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4029-32. doi: 10.1016/j.bmcl.2005.06.028. Bioorg Med Chem Lett. 2005. PMID: 15982881

9

Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists.

Han X, Michne JA, Pin SS, Burris KD, Balanda LA, Fung LK, Fiedler T, Browman KE, Taber MT, Zhang J, Dubowchik GM. Han X, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3870-3. doi: 10.1016/j.bmcl.2005.05.117. Bioorg Med Chem Lett. 2005. PMID: 15990298

10

Regioselective protection at N-2 and derivatization at C-3 of indazoles.

Luo G, Chen L, Dubowchik G. Luo G, et al. J Org Chem. 2006 Jul 7;71(14):5392-5. doi: 10.1021/jo060607j. J Org Chem. 2006. PMID: 16808535

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