Fraser R - Search Results

1

Effects of genetic variation in the aldosterone synthase (CYP11B2) gene on enzyme function.

Holloway CD, MacKenzie SM, Fraser R, Miller S, Barr M, Wilkinson D, Forbes GH, Friel E, Connell JM, Davies E. Holloway CD, et al. Among authors: fraser r. Clin Endocrinol (Oxf). 2009 Mar;70(3):363-71. doi: 10.1111/j.1365-2265.2008.03383.x. Epub 2008 Aug 15. Clin Endocrinol (Oxf). 2009. PMID: 18710464

2

Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio.

Lim PO, Macdonald TM, Holloway C, Friel E, Anderson NH, Dow E, Jung RT, Davies E, Fraser R, Connell JM. Lim PO, et al. Among authors: fraser r. J Clin Endocrinol Metab. 2002 Sep;87(9):4398-402. doi: 10.1210/jc.2001-012070. J Clin Endocrinol Metab. 2002. PMID: 12213905

3

Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension?

Connell JM, Fraser R, MacKenzie S, Davies E. Connell JM, et al. Among authors: fraser r. Hypertension. 2003 May;41(5):993-9. doi: 10.1161/01.HYP.0000064344.00173.44. Epub 2003 Mar 24. Hypertension. 2003. PMID: 12654713 Review.

4

Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II.

Ye P, Kenyon CJ, MacKenzie SM, Seckl JR, Fraser R, Connell JM, Davies E. Ye P, et al. Among authors: fraser r. Endocrinology. 2003 Aug;144(8):3321-8. doi: 10.1210/en.2003-0109. Endocrinology. 2003. PMID: 12865309

5

The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation.

Connell JM, Fraser R, MacKenzie SM, Friel EC, Ingram MC, Holloway CD, Davies E. Connell JM, et al. Among authors: fraser r. Mol Cell Endocrinol. 2004 Mar 31;217(1-2):243-7. doi: 10.1016/j.mce.2003.10.025. Mol Cell Endocrinol. 2004. PMID: 15134824 Review.

6

Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjects.

Kennon B, Ingram MC, Friel EC, Anderson NH, MacKenzie SM, Davies E, Shakerdi L, Wallace AM, Fraser R, Connell JM. Kennon B, et al. Among authors: fraser r. Clin Endocrinol (Oxf). 2004 Aug;61(2):174-81. doi: 10.1111/j.1365-2265.2004.02073.x. Clin Endocrinol (Oxf). 2004. PMID: 15272911 Clinical Trial.

7

Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects.

Freel EM, Shakerdi LA, Friel EC, Wallace AM, Davies E, Fraser R, Connell JM. Freel EM, et al. Among authors: fraser r. J Clin Endocrinol Metab. 2004 Sep;89(9):4628-33. doi: 10.1210/jc.2004-0379. J Clin Endocrinol Metab. 2004. PMID: 15356073 Free PMC article.

8

Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.

Keavney B, Mayosi B, Gaukrodger N, Imrie H, Baker M, Fraser R, Ingram M, Watkins H, Farrall M, Davies E, Connell J. Keavney B, et al. Among authors: fraser r. J Clin Endocrinol Metab. 2005 Feb;90(2):1072-7. doi: 10.1210/jc.2004-0870. Epub 2004 Nov 2. J Clin Endocrinol Metab. 2005. PMID: 15522937

9

Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.

Barr M, MacKenzie SM, Friel EC, Holloway CD, Wilkinson DM, Brain NJ, Ingram MC, Fraser R, Brown M, Samani NJ, Caulfield M, Munroe PB, Farrall M, Webster J, Clayton D, Dominiczak AF, Connell JM, Davies E. Barr M, et al. Among authors: fraser r. Hypertension. 2007 Jan;49(1):113-9. doi: 10.1161/01.HYP.0000249904.93940.7a. Epub 2006 Oct 30. Hypertension. 2007. PMID: 17075029

10

Functional effects of genetic variants in the 11beta-hydroxylase (CYP11B1) gene.

Barr M, MacKenzie SM, Wilkinson DM, Holloway CD, Friel EC, Miller S, MacDonald T, Fraser R, Connell JM, Davies E. Barr M, et al. Among authors: fraser r. Clin Endocrinol (Oxf). 2006 Dec;65(6):816-25. doi: 10.1111/j.1365-2265.2006.02673.x. Clin Endocrinol (Oxf). 2006. PMID: 17121536

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