Zhang G - Search Results

1

Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.

Zhang G, Park MA, Mitchell C, Hamed H, Rahmani M, Martin AP, Curiel DT, Yacoub A, Graf M, Lee R, Roberts JD, Fisher PB, Grant S, Dent P. Zhang G, et al. Clin Cancer Res. 2008 Sep 1;14(17):5385-99. doi: 10.1158/1078-0432.CCR-08-0469. Clin Cancer Res. 2008. PMID: 18765530 Free PMC article.

2

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.

Mitchell C, Park MA, Zhang G, Yacoub A, Curiel DT, Fisher PB, Roberts JD, Grant S, Dent P. Mitchell C, et al. Among authors: zhang g. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3101-12. doi: 10.1158/1535-7163.MCT-07-0561. Epub 2007 Dec 7. Mol Cancer Ther. 2007. PMID: 18065490

3

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo.

Hamed H, Hawkins W, Mitchell C, Gilfor D, Zhang G, Pei XY, Dai Y, Hagan MP, Roberts JD, Yacoub A, Grant S, Dent P. Hamed H, et al. Among authors: zhang g. Mol Cancer Ther. 2008 Mar;7(3):616-29. doi: 10.1158/1535-7163.MCT-07-2376. Mol Cancer Ther. 2008. PMID: 18347148

4

Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.

Zhang G, Park MA, Mitchell C, Walker T, Hamed H, Studer E, Graf M, Rahmani M, Gupta S, Hylemon PB, Fisher PB, Grant S, Dent P. Zhang G, et al. J Biol Chem. 2008 Sep 5;283(36):24343-58. doi: 10.1074/jbc.M803444200. Epub 2008 Jul 9. J Biol Chem. 2008. PMID: 18614532 Free PMC article.

5

Regulation of autophagy by ceramide-CD95-PERK signaling.

Park MA, Zhang G, Norris J, Hylemon PB, Fisher PB, Grant S, Dent P. Park MA, et al. Among authors: zhang g. Autophagy. 2008 Oct;4(7):929-31. doi: 10.4161/auto.6732. Epub 2008 Oct 5. Autophagy. 2008. PMID: 18719356 Free PMC article.

6

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.

Park MA, Zhang G, Martin AP, Hamed H, Mitchell C, Hylemon PB, Graf M, Rahmani M, Ryan K, Liu X, Spiegel S, Norris J, Fisher PB, Grant S, Dent P. Park MA, et al. Among authors: zhang g. Cancer Biol Ther. 2008 Oct;7(10):1648-62. doi: 10.4161/cbt.7.10.6623. Epub 2008 Oct 12. Cancer Biol Ther. 2008. PMID: 18787411 Free PMC article.

7

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.

Park MA, Zhang G, Mitchell C, Rahmani M, Hamed H, Hagan MP, Yacoub A, Curiel DT, Fisher PB, Grant S, Dent P. Park MA, et al. Among authors: zhang g. Mol Cancer Ther. 2008 Sep;7(9):2633-48. doi: 10.1158/1535-7163.MCT-08-0400. Mol Cancer Ther. 2008. PMID: 18790746 Free PMC article.

8

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.

Park MA, Mitchell C, Zhang G, Yacoub A, Allegood J, Häussinger D, Reinehr R, Larner A, Spiegel S, Fisher PB, Voelkel-Johnson C, Ogretmen B, Grant S, Dent P. Park MA, et al. Among authors: zhang g. Cancer Res. 2010 Aug 1;70(15):6313-24. doi: 10.1158/0008-5472.CAN-10-0999. Epub 2010 Jul 14. Cancer Res. 2010. PMID: 20631069 Free PMC article.

9

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines.

Mitchell C, Park MA, Zhang G, Han SI, Harada H, Franklin RA, Yacoub A, Li PL, Hylemon PB, Grant S, Dent P. Mitchell C, et al. Among authors: zhang g. Mol Cancer Ther. 2007 Feb;6(2):618-32. doi: 10.1158/1535-7163.MCT-06-0532. Mol Cancer Ther. 2007. PMID: 17308059

10

OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells.

Park MA, Yacoub A, Rahmani M, Zhang G, Hart L, Hagan MP, Calderwood SK, Sherman MY, Koumenis C, Spiegel S, Chen CS, Graf M, Curiel DT, Fisher PB, Grant S, Dent P. Park MA, et al. Among authors: zhang g. Mol Pharmacol. 2008 Apr;73(4):1168-84. doi: 10.1124/mol.107.042697. Epub 2008 Jan 8. Mol Pharmacol. 2008. PMID: 18182481 Free PMC article.

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