Meijer L - Search Results

1

Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period.

Vougogiannopoulou K, Ferandin Y, Bettayeb K, Myrianthopoulos V, Lozach O, Fan Y, Johnson CH, Magiatis P, Skaltsounis AL, Mikros E, Meijer L. Vougogiannopoulou K, et al. Among authors: meijer l. J Med Chem. 2008 Oct 23;51(20):6421-31. doi: 10.1021/jm800648y. Epub 2008 Sep 25. J Med Chem. 2008. PMID: 18816110 Free PMC article.

2

Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.

Schoepfer J, Fretz H, Chaudhuri B, Muller L, Seeber E, Meijer L, Lozach O, Vangrevelinghe E, Furet P. Schoepfer J, et al. Among authors: meijer l. J Med Chem. 2002 Apr 25;45(9):1741-7. doi: 10.1021/jm0108348. J Med Chem. 2002. PMID: 11960485

3

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.

Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M, Endicott J, Vierfond JM, Meijer L. Mettey Y, et al. Among authors: meijer l. J Med Chem. 2003 Jan 16;46(2):222-36. doi: 10.1021/jm020319p. J Med Chem. 2003. PMID: 12519061

4

Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties.

Brachwitz K, Voigt B, Meijer L, Lozach O, Schächtele C, Molnár J, Hilgeroth A. Brachwitz K, et al. Among authors: meijer l. J Med Chem. 2003 Feb 27;46(5):876-9. doi: 10.1021/jm021090g. J Med Chem. 2003. PMID: 12593668

5

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.

Kunick C, Lauenroth K, Leost M, Meijer L, Lemcke T. Kunick C, et al. Among authors: meijer l. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. doi: 10.1016/j.bmcl.2003.10.062. Bioorg Med Chem Lett. 2004. PMID: 14698171

6

GSK-3-selective inhibitors derived from Tyrian purple indirubins.

Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P. Meijer L, et al. Chem Biol. 2003 Dec;10(12):1255-66. doi: 10.1016/j.chembiol.2003.11.010. Chem Biol. 2003. PMID: 14700633

7

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.

Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L. Polychronopoulos P, et al. Among authors: meijer l. J Med Chem. 2004 Feb 12;47(4):935-46. doi: 10.1021/jm031016d. J Med Chem. 2004. PMID: 14761195

8

Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A.

Erdogan-Orhan I, Sener B, de Rosa S, Perez-Baz J, Lozach O, Leost M, Rakhilin S, Meijer L. Erdogan-Orhan I, et al. Among authors: meijer l. Nat Prod Res. 2004 Feb;18(1):1-9. doi: 10.1080/1478641031000111534. Nat Prod Res. 2004. PMID: 14974610

9

Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins.

Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager GL, Nagy SR, Han D, Denison M, Ffrench M, Ryan XP, Magiatis P, Polychronopoulos P, Greengard P, Skaltsounis L, Meijer L. Knockaert M, et al. Among authors: meijer l. Oncogene. 2004 May 27;23(25):4400-12. doi: 10.1038/sj.onc.1207535. Oncogene. 2004. PMID: 15077192

10

Synthesis and target identification of hymenialdisine analogs.

Wan Y, Hur W, Cho CY, Liu Y, Adrian FJ, Lozach O, Bach S, Mayer T, Fabbro D, Meijer L, Gray NS. Wan Y, et al. Among authors: meijer l. Chem Biol. 2004 Feb;11(2):247-59. doi: 10.1016/j.chembiol.2004.01.015. Chem Biol. 2004. PMID: 15123286

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