Broughton HB - Search Results

1

The synthesis of azadirachtin: a potent insect antifeedant.

Ley SV, Abad-Somovilla A, Anderson JC, Ayats C, Bänteli R, Beckmann E, Boyer A, Brasca MG, Brice A, Broughton HB, Burke BJ, Cleator E, Craig D, Denholm AA, Denton RM, Durand-Reville T, Gobbi LB, Göbel M, Gray BL, Grossmann RB, Gutteridge CE, Hahn N, Harding SL, Jennens DC, Jennens L, Lovell PJ, Lovell HJ, de la Puente ML, Kolb HC, Koot WJ, Maslen SL, McCusker CF, Mattes A, Pape AR, Pinto A, Santafianos D, Scott JS, Smith SC, Somers AQ, Spilling CD, Stelzer F, Toogood PL, Turner RM, Veitch GE, Wood A, Zumbrunn C. Ley SV, et al. Among authors: broughton hb. Chemistry. 2008;14(34):10683-704. doi: 10.1002/chem.200801103. Chemistry. 2008. PMID: 18821532

2

Development of peptide 3D structure mimetics: rational design of novel peptoid cholecystokinin receptor antagonists.

Low CM, Black JW, Broughton HB, Buck IM, Davies JM, Dunstone DJ, Hull RA, Kalindjian SB, McDonald IM, Pether MJ, Shankley NP, Steel KI. Low CM, et al. Among authors: broughton hb. J Med Chem. 2000 Sep 21;43(19):3505-17. doi: 10.1021/jm000937a. J Med Chem. 2000. PMID: 11000005

3

5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.

Castro JL, Broughton HB, Russell MG, Rathbone D, Watt AP, Ball RG, Chapman KL, Patel S, Smith AJ, Marshall GR, Matassa VG. Castro JL, et al. Among authors: broughton hb. J Med Chem. 1997 Aug 1;40(16):2491-501. doi: 10.1021/jm9608523. J Med Chem. 1997. PMID: 9258356

4

Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.

Castro JL, Ball RG, Broughton HB, Russell MG, Rathbone D, Watt AP, Baker R, Chapman KL, Fletcher AE, Patel S, Smith AJ, Marshall GR, Ryecroft W, Matassa VG. Castro JL, et al. Among authors: broughton hb. J Med Chem. 1996 Feb 16;39(4):842-9. doi: 10.1021/jm9506736. J Med Chem. 1996. PMID: 8632408

5

N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.

Russell MG, Baker RJ, Barden L, Beer MS, Bristow L, Broughton HB, Knowles M, McAllister G, Patel S, Castro JL. Russell MG, et al. Among authors: broughton hb. J Med Chem. 2001 Nov 8;44(23):3881-95. doi: 10.1021/jm010943m. J Med Chem. 2001. PMID: 11689074

6

Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.

Chambers MS, Atack JR, Broughton HB, Collinson N, Cook S, Dawson GR, Hobbs SC, Marshall G, Maubach KA, Pillai GV, Reeve AJ, MacLeod AM. Chambers MS, et al. Among authors: broughton hb. J Med Chem. 2003 May 22;46(11):2227-40. doi: 10.1021/jm020582q. J Med Chem. 2003. PMID: 12747794

7

4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.

Rowley M, Collins I, Broughton HB, Davey WB, Baker R, Emms F, Marwood R, Patel S, Patel S, Ragan CI, Freedman SB, Ball R, Leeson PD. Rowley M, et al. Among authors: broughton hb. J Med Chem. 1997 Jul 18;40(15):2374-85. doi: 10.1021/jm970111h. J Med Chem. 1997. PMID: 9240352

8

6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.

Chambers MS, Atack JR, Bromidge FA, Broughton HB, Cook S, Dawson GR, Hobbs SC, Maubach KA, Reeve AJ, Seabrook GR, Wafford K, MacLeod AM. Chambers MS, et al. Among authors: broughton hb. J Med Chem. 2002 Mar 14;45(6):1176-9. doi: 10.1021/jm010471b. J Med Chem. 2002. PMID: 11881985

9

Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.

van Niel MB, Collins I, Beer MS, Broughton HB, Cheng SK, Goodacre SC, Heald A, Locker KL, MacLeod AM, Morrison D, Moyes CR, O'Connor D, Pike A, Rowley M, Russell MG, Sohal B, Stanton JA, Thomas S, Verrier H, Watt AP, Castro JL. van Niel MB, et al. Among authors: broughton hb. J Med Chem. 1999 Jun 17;42(12):2087-104. doi: 10.1021/jm981133m. J Med Chem. 1999. PMID: 10377215

10

3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists.

Russell MG, Matassa VG, Pengilley RR, van Niel MB, Sohal B, Watt AP, Hitzel L, Beer MS, Stanton JA, Broughton HB, Castro JL. Russell MG, et al. Among authors: broughton hb. J Med Chem. 1999 Dec 2;42(24):4981-5001. doi: 10.1021/jm9910021. J Med Chem. 1999. PMID: 10585208

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