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Page 1
Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227).
Seiwert SD, Andrews SW, Jiang Y, Serebryany V, Tan H, Kossen K, Rajagopalan PT, Misialek S, Stevens SK, Stoycheva A, Hong J, Lim SR, Qin X, Rieger R, Condroski KR, Zhang H, Do MG, Lemieux C, Hingorani GP, Hartley DP, Josey JA, Pan L, Beigelman L, Blatt LM. Seiwert SD, et al. Among authors: stoycheva a. Antimicrob Agents Chemother. 2008 Dec;52(12):4432-41. doi: 10.1128/AAC.00699-08. Epub 2008 Sep 29. Antimicrob Agents Chemother. 2008. PMID: 18824605 Free PMC article.
HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.
Wang G, Lei H, Wang X, Das D, Hong J, Mackinnon CH, Coulter TS, Montalbetti CA, Mears R, Gai X, Bailey SE, Ruhrmund D, Hooi L, Misialek S, Rajagopalan PT, Cheng RK, Barker JJ, Felicetti B, Schönfeld DL, Stoycheva A, Buckman BO, Kossen K, Seiwert SD, Beigelman L. Wang G, et al. Among authors: stoycheva a. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4480-3. doi: 10.1016/j.bmcl.2009.05.022. Epub 2009 May 9. Bioorg Med Chem Lett. 2009. PMID: 19500983
HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives.
Wang G, He Y, Sun J, Das D, Hu M, Huang J, Ruhrmund D, Hooi L, Misialek S, Ravi Rajagopalan PT, Stoycheva A, Buckman BO, Kossen K, Seiwert SD, Beigelman L. Wang G, et al. Among authors: stoycheva a. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4476-9. doi: 10.1016/j.bmcl.2009.05.063. Epub 2009 May 23. Bioorg Med Chem Lett. 2009. PMID: 19502055
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
Deval J, Hong J, Wang G, Taylor J, Smith LK, Fung A, Stevens SK, Liu H, Jin Z, Dyatkina N, Prhavc M, Stoycheva AD, Serebryany V, Liu J, Smith DB, Tam Y, Zhang Q, Moore ML, Fearns R, Chanda SM, Blatt LM, Symons JA, Beigelman L. Deval J, et al. Among authors: stoycheva ad. PLoS Pathog. 2015 Jun 22;11(6):e1004995. doi: 10.1371/journal.ppat.1004995. eCollection 2015 Jun. PLoS Pathog. 2015. PMID: 26098424 Free PMC article.
Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
Wang G, Dyatkina N, Prhavc M, Williams C, Serebryany V, Hu Y, Huang Y, Wan J, Wu X, Deval J, Fung A, Jin Z, Tan H, Shaw K, Kang H, Zhang Q, Tam Y, Stoycheva A, Jekle A, Smith DB, Beigelman L. Wang G, et al. Among authors: stoycheva a. J Med Chem. 2019 May 9;62(9):4555-4570. doi: 10.1021/acs.jmedchem.9b00143. Epub 2019 Apr 19. J Med Chem. 2019. PMID: 30951311
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
Wang G, Dyatkina N, Prhavc M, Williams C, Serebryany V, Hu Y, Huang Y, Wu X, Chen T, Huang W, Rajwanshi VK, Deval J, Fung A, Jin Z, Stoycheva A, Shaw K, Gupta K, Tam Y, Jekle A, Smith DB, Beigelman L. Wang G, et al. Among authors: stoycheva a. J Med Chem. 2020 Sep 24;63(18):10380-10395. doi: 10.1021/acs.jmedchem.0c00935. Epub 2020 Sep 3. J Med Chem. 2020. PMID: 32816483
Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).
Luong XG, Stevens SK, Jekle A, Lin TI, Gupta K, Misner D, Chanda S, Mukherjee S, Williams C, Stoycheva A, Blatt LM, Beigelman LN, Symons JA, Raboisson P, McGowan D, Vandyck K, Deval J. Luong XG, et al. Among authors: stoycheva a. PLoS One. 2020 Dec 11;15(12):e0240338. doi: 10.1371/journal.pone.0240338. eCollection 2020. PLoS One. 2020. PMID: 33306682 Free PMC article.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Vandyck K, Abdelnabi R, Gupta K, Jochmans D, Jekle A, Deval J, Misner D, Bardiot D, Foo CS, Liu C, Ren S, Beigelman L, Blatt LM, Boland S, Vangeel L, Dejonghe S, Chaltin P, Marchand A, Serebryany V, Stoycheva A, Chanda S, Symons JA, Raboisson P, Neyts J. Vandyck K, et al. Among authors: stoycheva a. Biochem Biophys Res Commun. 2021 May 28;555:134-139. doi: 10.1016/j.bbrc.2021.03.096. Epub 2021 Mar 26. Biochem Biophys Res Commun. 2021. PMID: 33813272 Free PMC article.
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
Jochmans D, Liu C, Donckers K, Stoycheva A, Boland S, Stevens SK, De Vita C, Vanmechelen B, Maes P, Trüeb B, Ebert N, Thiel V, De Jonghe S, Vangeel L, Bardiot D, Jekle A, Blatt LM, Beigelman L, Symons JA, Raboisson P, Chaltin P, Marchand A, Neyts J, Deval J, Vandyck K. Jochmans D, et al. Among authors: stoycheva a. mBio. 2023 Feb 28;14(1):e0281522. doi: 10.1128/mbio.02815-22. Epub 2023 Jan 10. mBio. 2023. PMID: 36625640 Free PMC article.
20 results