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Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide.
Feldt S, Batenburg WW, Mazak I, Maschke U, Wellner M, Kvakan H, Dechend R, Fiebeler A, Burckle C, Contrepas A, Jan Danser AH, Bader M, Nguyen G, Luft FC, Muller DN. Feldt S, et al. Among authors: jan danser ah. Hypertension. 2008 Mar;51(3):682-8. doi: 10.1161/HYPERTENSIONAHA.107.101444. Epub 2008 Jan 22. Hypertension. 2008. PMID: 18212269
Aliskiren accumulates in Renin secretory granules and binds plasma prorenin.
Krop M, Garrelds IM, de Bruin RJ, van Gool JM, Fisher ND, Hollenberg NK, Jan Danser AH. Krop M, et al. Among authors: jan danser ah. Hypertension. 2008 Dec;52(6):1076-83. doi: 10.1161/HYPERTENSIONAHA.108.123042. Epub 2008 Nov 3. Hypertension. 2008. PMID: 18981317 Clinical Trial.
Elevated blood pressure and heart rate in human renin receptor transgenic rats.
Burcklé CA, Jan Danser AH, Müller DN, Garrelds IM, Gasc JM, Popova E, Plehm R, Peters J, Bader M, Nguyen G. Burcklé CA, et al. Among authors: jan danser ah. Hypertension. 2006 Mar;47(3):552-6. doi: 10.1161/01.HYP.0000199912.47657.04. Epub 2006 Jan 9. Hypertension. 2006. PMID: 16401765
55 results