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Aliskiren accumulates in Renin secretory granules and binds plasma prorenin.
Krop M, Garrelds IM, de Bruin RJ, van Gool JM, Fisher ND, Hollenberg NK, Jan Danser AH. Krop M, et al. Among authors: garrelds im. Hypertension. 2008 Dec;52(6):1076-83. doi: 10.1161/HYPERTENSIONAHA.108.123042. Epub 2008 Nov 3. Hypertension. 2008. PMID: 18981317 Clinical Trial.
Elevated blood pressure and heart rate in human renin receptor transgenic rats.
Burcklé CA, Jan Danser AH, Müller DN, Garrelds IM, Gasc JM, Popova E, Plehm R, Peters J, Bader M, Nguyen G. Burcklé CA, et al. Among authors: garrelds im. Hypertension. 2006 Mar;47(3):552-6. doi: 10.1161/01.HYP.0000199912.47657.04. Epub 2006 Jan 9. Hypertension. 2006. PMID: 16401765
Cardiac Renin levels are not influenced by the amount of resident mast cells.
Krop M, van Veghel R, Garrelds IM, de Bruin RJ, van Gool JM, van den Meiracker AH, Thio M, van Daele PL, Danser AH. Krop M, et al. Among authors: garrelds im. Hypertension. 2009 Aug;54(2):315-21. doi: 10.1161/HYPERTENSIONAHA.109.133892. Epub 2009 Jun 29. Hypertension. 2009. PMID: 19564544
129 results