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Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity.
Tiberghien AC, Vijayakrishnan B, Esfandiari A, Ahmed M, Pardo R, Bingham J, Adams L, Santos K, Kang GD, Pugh KM, Afif-Rider S, Vashisht K, Haque K, Tammali R, Rosfjord E, Savoca A, Hartley JA, Howard PW. Tiberghien AC, et al. Among authors: kang gd. Mol Cancer Ther. 2023 Feb 1;22(2):254-263. doi: 10.1158/1535-7163.MCT-21-0693. Mol Cancer Ther. 2023. PMID: 36722141
Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody-Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer.
Gregson SJ, Pugh K, Patel N, Afif-Rider S, Vijayakrishnan B, Santos K, Riedl J, Hutchinson I, Kang GD, Chooi KP, Beard R, Adams L, Barry CS, Ball K, Masterson LA, McFarlane M, Hartley JA, Howard PW. Gregson SJ, et al. Among authors: kang gd. Mol Cancer Ther. 2022 Sep 6;21(9):1439-1448. doi: 10.1158/1535-7163.MCT-22-0145. Mol Cancer Ther. 2022. PMID: 35793464
Simultaneous monitoring of multiple attributes of pyrrolobenzodiazepine antibody-drug conjugates by size exclusion chromatography - high resolution mass spectrometry.
Füssl F, Barry CS, Pugh KM, Chooi KP, Vijayakrishnan B, Kang GD, von Bulow C, Howard PW, Bones J. Füssl F, et al. Among authors: kang gd. J Pharm Biomed Anal. 2021 Oct 25;205:114287. doi: 10.1016/j.jpba.2021.114287. Epub 2021 Jul 28. J Pharm Biomed Anal. 2021. PMID: 34385015 Free article.
Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers.
Gregson SJ, Barrett AM, Patel NV, Kang GD, Schiavone D, Sult E, Barry CS, Vijayakrishnan B, Adams LR, Masterson LA, D'Hooge F, Snaith M, Harper J, Hartley JA, Howard PW. Gregson SJ, et al. Among authors: kang gd. Eur J Med Chem. 2019 Oct 1;179:591-607. doi: 10.1016/j.ejmech.2019.06.044. Epub 2019 Jun 18. Eur J Med Chem. 2019. PMID: 31279293
Potentiation of PBD Dimers by Lipophilicity Manipulation.
Cailleau T, Adams LR, Arora N, Kang GD, Masterson L, Patel N, Hartley JA, Mao S, Harper J, Howard PW. Cailleau T, et al. Among authors: kang gd. Curr Top Med Chem. 2019;19(9):741-752. doi: 10.2174/1568026619666190401112517. Curr Top Med Chem. 2019. PMID: 30931859
Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.
Gregson SJ, Masterson LA, Wei B, Pillow TH, Spencer SD, Kang GD, Yu SF, Raab H, Lau J, Li G, Lewis Phillips GD, Gunzner-Toste J, Safina BS, Ohri R, Darwish M, Kozak KR, Dela Cruz-Chuh J, Polson A, Flygare JA, Howard PW. Gregson SJ, et al. Among authors: kang gd. J Med Chem. 2017 Dec 14;60(23):9490-9507. doi: 10.1021/acs.jmedchem.7b00736. Epub 2017 Nov 16. J Med Chem. 2017. PMID: 29112410
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