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VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation.
Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Nagy JA, Joyce J, Bogyo M, Kalluri R, Dvorak HF. Chang SH, et al. Among authors: shih sc. Cancer Res. 2009 May 15;69(10):4537-44. doi: 10.1158/0008-5472.CAN-08-4539. Epub 2009 May 12. Cancer Res. 2009. PMID: 19435903 Free PMC article.
Heterogeneity of the tumor vasculature.
Nagy JA, Chang SH, Shih SC, Dvorak AM, Dvorak HF. Nagy JA, et al. Among authors: shih sc. Semin Thromb Hemost. 2010 Apr;36(3):321-31. doi: 10.1055/s-0030-1253454. Epub 2010 May 20. Semin Thromb Hemost. 2010. PMID: 20490982 Free PMC article. Review.
318 results