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Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration.
Leonetti C, Amodei S, D'Angelo C, Rizzo A, Benassi B, Antonelli A, Elli R, Stevens MF, D'Incalci M, Zupi G, Biroccio A. Leonetti C, et al. Among authors: rizzo a. Mol Pharmacol. 2004 Nov;66(5):1138-46. doi: 10.1124/mol.104.001537. Epub 2004 Aug 10. Mol Pharmacol. 2004. PMID: 15304549
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
Salvati E, Leonetti C, Rizzo A, Scarsella M, Mottolese M, Galati R, Sperduti I, Stevens MF, D'Incalci M, Blasco M, Chiorino G, Bauwens S, Horard B, Gilson E, Stoppacciaro A, Zupi G, Biroccio A. Salvati E, et al. Among authors: rizzo a. J Clin Invest. 2007 Nov;117(11):3236-47. doi: 10.1172/JCI32461. J Clin Invest. 2007. PMID: 17932567 Free PMC article.
Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.
Chevanne M, Zampieri M, Caldini R, Rizzo A, Ciccarone F, Catizone A, D'Angelo C, Guastafierro T, Biroccio A, Reale A, Zupi G, Caiafa P. Chevanne M, et al. Among authors: rizzo a. J Cell Physiol. 2010 Feb;222(2):401-10. doi: 10.1002/jcp.21964. J Cell Physiol. 2010. PMID: 19890834
N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.
Casagrande V, Salvati E, Alvino A, Bianco A, Ciammaichella A, D'Angelo C, Ginnari-Satriani L, Serrilli AM, Iachettini S, Leonetti C, Neidle S, Ortaggi G, Porru M, Rizzo A, Franceschin M, Biroccio A. Casagrande V, et al. Among authors: rizzo a. J Med Chem. 2011 Mar 10;54(5):1140-56. doi: 10.1021/jm1013665. Epub 2011 Jan 31. J Med Chem. 2011. PMID: 21280624
DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents.
Biroccio A, Porru M, Rizzo A, Salvati E, D'Angelo C, Orlandi A, Passeri D, Franceschin M, Stevens MF, Gilson E, Beretta G, Zupi G, Pisano C, Zunino F, Leonetti C. Biroccio A, et al. Among authors: rizzo a. Clin Cancer Res. 2011 Apr 15;17(8):2227-36. doi: 10.1158/1078-0432.CCR-10-3033. Epub 2011 Feb 25. Clin Cancer Res. 2011. PMID: 21355072
1,985 results