Arner EC - Search Results

1

Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation.

Malfait AM, Tortorella M, Thompson J, Hills R, Meyer DM, Jaffee BD, Chinn K, Ghoreishi-Haack N, Markosyan S, Arner EC. Malfait AM, et al. Among authors: arner ec. Osteoarthritis Cartilage. 2009 May;17(5):627-35. doi: 10.1016/j.joca.2008.10.005. Epub 2008 Nov 1. Osteoarthritis Cartilage. 2009. PMID: 19026578 Free article.

2

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, Griggs DW. Song RH, et al. Among authors: arner ec. Arthritis Rheum. 2007 Feb;56(2):575-85. doi: 10.1002/art.22334. Arthritis Rheum. 2007. PMID: 17265492 Free article.

3

The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.

Tortorella MD, Malfait AM, Deccico C, Arner E. Tortorella MD, et al. Osteoarthritis Cartilage. 2001 Aug;9(6):539-52. doi: 10.1053/joca.2001.0427. Osteoarthritis Cartilage. 2001. PMID: 11520168 Free article.

4

Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.

Arner EC, Hughes CE, Decicco CP, Caterson B, Tortorella MD. Arner EC, et al. Osteoarthritis Cartilage. 1998 May;6(3):214-28. doi: 10.1053/joca.1998.0114. Osteoarthritis Cartilage. 1998. PMID: 9682788 Free article.

5

Identification of fibronectin neoepitopes present in human osteoarthritic cartilage.

Zack MD, Arner EC, Anglin CP, Alston JT, Malfait AM, Tortorella MD. Zack MD, et al. Among authors: arner ec. Arthritis Rheum. 2006 Sep;54(9):2912-22. doi: 10.1002/art.22045. Arthritis Rheum. 2006. PMID: 16948117 Free article.

6

Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).

Wittwer AJ, Hills RL, Keith RH, Munie GE, Arner EC, Anglin CP, Malfait AM, Tortorella MD. Wittwer AJ, et al. Among authors: arner ec. Biochemistry. 2007 May 29;46(21):6393-401. doi: 10.1021/bi7000642. Epub 2007 May 8. Biochemistry. 2007. PMID: 17487981

7

Proprotein convertase activation of aggrecanases in cartilage in situ.

Malfait AM, Arner EC, Song RH, Alston JT, Markosyan S, Staten N, Yang Z, Griggs DW, Tortorella MD. Malfait AM, et al. Among authors: arner ec. Arch Biochem Biophys. 2008 Oct 1;478(1):43-51. doi: 10.1016/j.abb.2008.07.012. Epub 2008 Jul 19. Arch Biochem Biophys. 2008. PMID: 18671934

8

ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271).

Zack MD, Malfait AM, Skepner AP, Yates MP, Griggs DW, Hall T, Hills RL, Alston JT, Nemirovskiy OV, Radabaugh MR, Leone JW, Arner EC, Tortorella MD. Zack MD, et al. Among authors: arner ec. Arthritis Rheum. 2009 Sep;60(9):2704-13. doi: 10.1002/art.24753. Arthritis Rheum. 2009. PMID: 19714641 Free article.

9

Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.

Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, Wittwer AJ, Liu RQ, Malfait AM. Tortorella MD, et al. Among authors: arner ec. J Biol Chem. 2004 Apr 23;279(17):17554-61. doi: 10.1074/jbc.M313041200. Epub 2004 Jan 7. J Biol Chem. 2004. PMID: 14715656 Free article.

10

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).

Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A. Shieh HS, et al. Among authors: arner ec. J Biol Chem. 2008 Jan 18;283(3):1501-1507. doi: 10.1074/jbc.M705879200. Epub 2007 Nov 8. J Biol Chem. 2008. PMID: 17991750 Free article.

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