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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
Sonveaux P, Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, De Saedeleer CJ, Kennedy KM, Diepart C, Jordan BF, Kelley MJ, Gallez B, Wahl ML, Feron O, Dewhirst MW. Sonveaux P, et al. Among authors: kennedy km. J Clin Invest. 2008 Dec;118(12):3930-42. doi: 10.1172/JCI36843. Epub 2008 Nov 20. J Clin Invest. 2008. PMID: 19033663 Free PMC article.
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
Sonveaux P, Copetti T, De Saedeleer CJ, Végran F, Verrax J, Kennedy KM, Moon EJ, Dhup S, Danhier P, Frérart F, Gallez B, Ribeiro A, Michiels C, Dewhirst MW, Feron O. Sonveaux P, et al. Among authors: kennedy km. PLoS One. 2012;7(3):e33418. doi: 10.1371/journal.pone.0033418. Epub 2012 Mar 13. PLoS One. 2012. PMID: 22428047 Free PMC article.
Individual responses to chemotherapy-induced oxidative stress.
Il'yasova D, Kennedy K, Spasojevic I, Wang F, Tolun AA, Base K, Young SP, Kelly Marcom P, Marks J, Millington DS, Dewhirst MW. Il'yasova D, et al. Breast Cancer Res Treat. 2011 Jan;125(2):583-9. doi: 10.1007/s10549-010-1158-7. Epub 2010 Sep 10. Breast Cancer Res Treat. 2011. PMID: 20830514 Free PMC article.
195 results