Thorne N - Search Results

1

A robotic platform for quantitative high-throughput screening.

Michael S, Auld D, Klumpp C, Jadhav A, Zheng W, Thorne N, Austin CP, Inglese J, Simeonov A. Michael S, et al. Among authors: thorne n. Assay Drug Dev Technol. 2008 Oct;6(5):637-57. doi: 10.1089/adt.2008.150. Assay Drug Dev Technol. 2008. PMID: 19035846 Free PMC article. Review.

2

Apparent activity in high-throughput screening: origins of compound-dependent assay interference.

Thorne N, Auld DS, Inglese J. Thorne N, et al. Curr Opin Chem Biol. 2010 Jun;14(3):315-24. doi: 10.1016/j.cbpa.2010.03.020. Epub 2010 Apr 22. Curr Opin Chem Biol. 2010. PMID: 20417149 Free PMC article. Review.

3

A specific mechanism for nonspecific activation in reporter-gene assays.

Auld DS, Thorne N, Nguyen DT, Inglese J. Auld DS, et al. Among authors: thorne n. ACS Chem Biol. 2008 Aug 15;3(8):463-70. doi: 10.1021/cb8000793. Epub 2008 Jul 1. ACS Chem Biol. 2008. PMID: 18590332 Free PMC article.

4

Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression.

Auld DS, Thorne N, Maguire WF, Inglese J. Auld DS, et al. Among authors: thorne n. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3585-90. doi: 10.1073/pnas.0813345106. Epub 2009 Feb 10. Proc Natl Acad Sci U S A. 2009. PMID: 19208811 Free PMC article.

5

Evaluation of cholesterol reduction activity of methyl-β-cyclodextrin using differentiated human neurons and astrocytes.

Swaroop M, Thorne N, Rao MS, Austin CP, McKew JC, Zheng W. Swaroop M, et al. Among authors: thorne n. J Biomol Screen. 2012 Oct;17(9):1243-51. doi: 10.1177/1087057112456877. Epub 2012 Aug 24. J Biomol Screen. 2012. PMID: 22923786 Free PMC article.

6

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J. Auld DS, et al. Among authors: thorne n. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. doi: 10.1073/pnas.0909141107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194791 Free PMC article.

7

Illuminating insights into firefly luciferase and other bioluminescent reporters used in chemical biology.

Thorne N, Inglese J, Auld DS. Thorne N, et al. Chem Biol. 2010 Jun 25;17(6):646-57. doi: 10.1016/j.chembiol.2010.05.012. Chem Biol. 2010. PMID: 20609414 Free PMC article. Review.

8

A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.

Davis MI, Sasaki AT, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simeonov A. Davis MI, et al. Among authors: thorne n. PLoS One. 2013;8(1):e54127. doi: 10.1371/journal.pone.0054127. Epub 2013 Jan 10. PLoS One. 2013. PMID: 23326584 Free PMC article.

9

High-throughput viability assay using an autonomously bioluminescent cell line with a bacterial Lux reporter.

Class B, Thorne N, Aguisanda F, Southall N, McKew JC, Zheng W. Class B, et al. Among authors: thorne n. J Lab Autom. 2015 Apr;20(2):164-74. doi: 10.1177/2211068214560608. Epub 2014 Dec 1. J Lab Autom. 2015. PMID: 25447977

10

Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.

Thorne N, Shen M, Lea WA, Simeonov A, Lovell S, Auld DS, Inglese J. Thorne N, et al. Chem Biol. 2012 Aug 24;19(8):1060-72. doi: 10.1016/j.chembiol.2012.07.015. Chem Biol. 2012. PMID: 22921073 Free PMC article.

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