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Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas.
Lee KY, Geng H, Ng KM, Yu J, van Hasselt A, Cao Y, Zeng YX, Wong AH, Wang X, Ying J, Srivastava G, Lung ML, Wang LD, Kwok TT, Levi BZ, Chan AT, Sung JJ, Tao Q. Lee KY, et al. Among authors: geng h. Oncogene. 2008 Sep 4;27(39):5267-76. doi: 10.1038/onc.2008.147. Epub 2008 May 12. Oncogene. 2008. PMID: 18469857
CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis.
Wang Y, Li J, Cui Y, Li T, Ng KM, Geng H, Li H, Shu XS, Li H, Liu W, Luo B, Zhang Q, Mok TS, Zheng W, Qiu X, Srivastava G, Yu J, Sung JJ, Chan AT, Ma D, Tao Q, Han W. Wang Y, et al. Among authors: geng h. Cancer Res. 2009 Jun 15;69(12):5194-201. doi: 10.1158/0008-5472.CAN-08-3694. Epub 2009 Jun 9. Cancer Res. 2009. PMID: 19509237
Epigenetic silencing of a proapoptotic cell adhesion molecule, the immunoglobulin superfamily member IGSF4, by promoter CpG methylation protects Hodgkin lymphoma cells from apoptosis.
Murray PG, Fan Y, Davies G, Ying J, Geng H, Ng KM, Li H, Gao Z, Wei W, Bose S, Anderton J, Kapatai G, Reynolds G, Ito A, Marafioti T, Woodman CB, Ambinder R, Tao Q. Murray PG, et al. Among authors: geng h. Am J Pathol. 2010 Sep;177(3):1480-90. doi: 10.2353/ajpath.2010.100052. Epub 2010 Aug 13. Am J Pathol. 2010. PMID: 20709797 Free PMC article.
The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors.
Shu XS, Geng H, Li L, Ying J, Ma C, Wang Y, Poon FF, Wang X, Ying Y, Yeo W, Srivastava G, Tsao SW, Yu J, Sung JJ, Huang S, Chan AT, Tao Q. Shu XS, et al. Among authors: geng h. PLoS One. 2011;6(11):e27346. doi: 10.1371/journal.pone.0027346. Epub 2011 Nov 8. PLoS One. 2011. PMID: 22087297 Free PMC article.
1,881 results