Zhang Q - Search Results

1

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).

Marzec M, Zhang Q, Goradia A, Raghunath PN, Liu X, Paessler M, Wang HY, Wysocka M, Cheng M, Ruggeri BA, Wasik MA. Marzec M, et al. Among authors: zhang q. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20852-7. doi: 10.1073/pnas.0810958105. Epub 2008 Dec 16. Proc Natl Acad Sci U S A. 2008. PMID: 19088198 Free PMC article.

2

STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.

Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA. Zhang Q, et al. Proc Natl Acad Sci U S A. 2005 May 10;102(19):6948-53. doi: 10.1073/pnas.0501959102. Epub 2005 May 3. Proc Natl Acad Sci U S A. 2005. PMID: 15870198 Free PMC article.

3

Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3.

Marzec M, Kasprzycka M, Ptasznik A, Wlodarski P, Zhang Q, Odum N, Wasik MA. Marzec M, et al. Among authors: zhang q. Lab Invest. 2005 Dec;85(12):1544-54. doi: 10.1038/labinvest.3700348. Lab Invest. 2005. PMID: 16170336 Free article.

4

Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.

Kasprzycka M, Majewski M, Wang ZJ, Ptasznik A, Wysocka M, Zhang Q, Marzec M, Gimotty P, Crompton MR, Wasik MA. Kasprzycka M, et al. Among authors: zhang q. Am J Pathol. 2006 May;168(5):1631-41. doi: 10.2353/ajpath.2006.050521. Am J Pathol. 2006. PMID: 16651629 Free PMC article.

5

Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3.

Kasprzycka M, Marzec M, Liu X, Zhang Q, Wasik MA. Kasprzycka M, et al. Among authors: zhang q. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9964-9. doi: 10.1073/pnas.0603507103. Epub 2006 Jun 9. Proc Natl Acad Sci U S A. 2006. PMID: 16766651 Free PMC article.

6

STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.

Zhang Q, Wang HY, Woetmann A, Raghunath PN, Odum N, Wasik MA. Zhang Q, et al. Blood. 2006 Aug 1;108(3):1058-64. doi: 10.1182/blood-2005-08-007377. Blood. 2006. PMID: 16861352 Free PMC article.

7

STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression.

Zhang Q, Wang HY, Liu X, Wasik MA. Zhang Q, et al. Nat Med. 2007 Nov;13(11):1341-8. doi: 10.1038/nm1659. Epub 2007 Oct 7. Nat Med. 2007. PMID: 17922009

8

Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches.

Wasik MA, Zhang Q, Marzec M, Kasprzycka M, Wang HY, Liu X. Wasik MA, et al. Among authors: zhang q. Semin Oncol. 2009 Apr;36(2 Suppl 1):S27-35. doi: 10.1053/j.seminoncol.2009.02.007. Semin Oncol. 2009. PMID: 19393833

9

Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+ TCL) cells from apoptosis.

Zhang Q, Wang HY, Bhutani G, Liu X, Paessler M, Tobias JW, Baldwin D, Swaminathan K, Milone MC, Wasik MA. Zhang Q, et al. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15843-8. doi: 10.1073/pnas.0907070106. Epub 2009 Aug 26. Proc Natl Acad Sci U S A. 2009. PMID: 19717436 Free PMC article.

10

IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.

Zhang Q, Wang HY, Liu X, Bhutani G, Kantekure K, Wasik M. Zhang Q, et al. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11977-82. doi: 10.1073/pnas.1100319108. Epub 2011 Jun 29. Proc Natl Acad Sci U S A. 2011. PMID: 21715655 Free PMC article.

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