Igaz LM - Search Results

1

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.

Igaz LM, Kwong LK, Chen-Plotkin A, Winton MJ, Unger TL, Xu Y, Neumann M, Trojanowski JQ, Lee VM. Igaz LM, et al. J Biol Chem. 2009 Mar 27;284(13):8516-24. doi: 10.1074/jbc.M809462200. Epub 2009 Jan 21. J Biol Chem. 2009. PMID: 19164285 Free PMC article.

2

Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.

Geser F, Winton MJ, Kwong LK, Xu Y, Xie SX, Igaz LM, Garruto RM, Perl DP, Galasko D, Lee VM, Trojanowski JQ. Geser F, et al. Among authors: igaz lm. Acta Neuropathol. 2008 Jan;115(1):133-45. doi: 10.1007/s00401-007-0257-y. Epub 2007 Aug 23. Acta Neuropathol. 2008. PMID: 17713769

3

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.

Winton MJ, Igaz LM, Wong MM, Kwong LK, Trojanowski JQ, Lee VM. Winton MJ, et al. Among authors: igaz lm. J Biol Chem. 2008 May 9;283(19):13302-9. doi: 10.1074/jbc.M800342200. Epub 2008 Feb 27. J Biol Chem. 2008. PMID: 18305110 Free PMC article.

4

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Igaz LM, Kwong LK, Xu Y, Truax AC, Uryu K, Neumann M, Clark CM, Elman LB, Miller BL, Grossman M, McCluskey LF, Trojanowski JQ, Lee VM. Igaz LM, et al. Am J Pathol. 2008 Jul;173(1):182-94. doi: 10.2353/ajpath.2008.080003. Epub 2008 Jun 5. Am J Pathol. 2008. PMID: 18535185 Free PMC article.

5

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.

Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM. Igaz LM, et al. J Clin Invest. 2011 Feb;121(2):726-38. doi: 10.1172/JCI44867. Epub 2011 Jan 4. J Clin Invest. 2011. PMID: 21206091 Free PMC article.

6

Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.

Neumann M, Igaz LM, Kwong LK, Nakashima-Yasuda H, Kolb SJ, Dreyfuss G, Kretzschmar HA, Trojanowski JQ, Lee VM. Neumann M, et al. Among authors: igaz lm. Acta Neuropathol. 2007 May;113(5):543-8. doi: 10.1007/s00401-007-0221-x. Epub 2007 Apr 6. Acta Neuropathol. 2007. PMID: 17415574

7

Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies.

Alfieri JA, Pino NS, Igaz LM. Alfieri JA, et al. Among authors: igaz lm. J Neurosci. 2014 Nov 12;34(46):15244-59. doi: 10.1523/JNEUROSCI.1918-14.2014. J Neurosci. 2014. PMID: 25392493 Free PMC article.

8

Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice.

Alfieri JA, Silva PR, Igaz LM. Alfieri JA, et al. Among authors: igaz lm. Front Aging Neurosci. 2016 Dec 20;8:310. doi: 10.3389/fnagi.2016.00310. eCollection 2016. Front Aging Neurosci. 2016. PMID: 28066234 Free PMC article.

9

Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice.

Silva PR, Nieva GV, Igaz LM. Silva PR, et al. Among authors: igaz lm. Front Genet. 2019 Apr 24;10:369. doi: 10.3389/fgene.2019.00369. eCollection 2019. Front Genet. 2019. PMID: 31068973 Free PMC article.

10

Cytoplasmic Expression of the ALS/FTD-Related Protein TDP-43 Decreases Global Translation Both in vitro and in vivo.

Charif SE, Luchelli L, Vila A, Blaustein M, Igaz LM. Charif SE, et al. Among authors: igaz lm. Front Cell Neurosci. 2020 Dec 8;14:594561. doi: 10.3389/fncel.2020.594561. eCollection 2020. Front Cell Neurosci. 2020. PMID: 33363456 Free PMC article.

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