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Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity.
Mendoza-Ferri MG, Hartinger CG, Mendoza MA, Groessl M, Egger AE, Eichinger RE, Mangrum JB, Farrell NP, Maruszak M, Bednarski PJ, Klein F, Jakupec MA, Nazarov AA, Severin K, Keppler BK. Mendoza-Ferri MG, et al. Among authors: eichinger re. J Med Chem. 2009 Feb 26;52(4):916-25. doi: 10.1021/jm8013234. J Med Chem. 2009. PMID: 19170599 Free PMC article.
Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and antiproliferative activity.
Groessl M, Reisner E, Hartinger CG, Eichinger R, Semenova O, Timerbaev AR, Jakupec MA, Arion VB, Keppler BK. Groessl M, et al. J Med Chem. 2007 May 3;50(9):2185-93. doi: 10.1021/jm061081y. Epub 2007 Apr 3. J Med Chem. 2007. PMID: 17402720