Staufenbiel M - Search Results

1

Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.

Machauer R, Laumen K, Veenstra S, Rondeau JM, Tintelnot-Blomley M, Betschart C, Jaton AL, Desrayaud S, Staufenbiel M, Rabe S, Paganetti P, Neumann U. Machauer R, et al. Among authors: staufenbiel m. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1366-70. doi: 10.1016/j.bmcl.2009.01.055. Epub 2009 Jan 22. Bioorg Med Chem Lett. 2009. PMID: 19195887

2

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

Bodendorf U, Danner S, Fischer F, Stefani M, Sturchler-Pierrat C, Wiederhold KH, Staufenbiel M, Paganetti P. Bodendorf U, et al. Among authors: staufenbiel m. J Neurochem. 2002 Mar;80(5):799-806. doi: 10.1046/j.0022-3042.2002.00770.x. J Neurochem. 2002. PMID: 11948243 Free article.

3

In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe.

Hintersteiner M, Enz A, Frey P, Jaton AL, Kinzy W, Kneuer R, Neumann U, Rudin M, Staufenbiel M, Stoeckli M, Wiederhold KH, Gremlich HU. Hintersteiner M, et al. Among authors: staufenbiel m. Nat Biotechnol. 2005 May;23(5):577-83. doi: 10.1038/nbt1085. Epub 2005 Apr 17. Nat Biotechnol. 2005. PMID: 15834405

4

BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice.

Herzig MC, Paganetti P, Staufenbiel M, Jucker M. Herzig MC, et al. Among authors: staufenbiel m. Neurodegener Dis. 2007;4(2-3):127-35. doi: 10.1159/000101837. Neurodegener Dis. 2007. PMID: 17596707

5

Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.

Abramowski D, Wiederhold KH, Furrer U, Jaton AL, Neuenschwander A, Runser MJ, Danner S, Reichwald J, Ammaturo D, Staab D, Stoeckli M, Rueeger H, Neumann U, Staufenbiel M. Abramowski D, et al. Among authors: staufenbiel m. J Pharmacol Exp Ther. 2008 Nov;327(2):411-24. doi: 10.1124/jpet.108.140327. Epub 2008 Aug 7. J Pharmacol Exp Ther. 2008. PMID: 18687920

6

Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.

Lerchner A, Machauer R, Betschart C, Veenstra S, Rueeger H, McCarthy C, Tintelnot-Blomley M, Jaton AL, Rabe S, Desrayaud S, Enz A, Staufenbiel M, Paganetti P, Rondeau JM, Neumann U. Lerchner A, et al. Among authors: staufenbiel m. Bioorg Med Chem Lett. 2010 Jan 15;20(2):603-7. doi: 10.1016/j.bmcl.2009.11.092. Epub 2009 Nov 22. Bioorg Med Chem Lett. 2010. PMID: 19963375

7

beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.

Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. Sala Frigerio C, et al. Among authors: staufenbiel m. FEBS J. 2010 Mar;277(6):1503-18. doi: 10.1111/j.1742-4658.2010.07579.x. Epub 2010 Feb 15. FEBS J. 2010. PMID: 20163459 Free PMC article.

8

Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice.

Winkler DT, Abramowski D, Danner S, Zurini M, Paganetti P, Tolnay M, Staufenbiel M. Winkler DT, et al. Among authors: staufenbiel m. Biol Psychiatry. 2010 Nov 15;68(10):971-4. doi: 10.1016/j.biopsych.2010.01.030. Epub 2010 Mar 31. Biol Psychiatry. 2010. PMID: 20359696

9

Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid.

Schieb H, Kratzin H, Jahn O, Möbius W, Rabe S, Staufenbiel M, Wiltfang J, Klafki HW. Schieb H, et al. Among authors: staufenbiel m. J Biol Chem. 2011 Sep 30;286(39):33747-58. doi: 10.1074/jbc.M111.246561. Epub 2011 Jul 27. J Biol Chem. 2011. PMID: 21795681 Free PMC article.

10

The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.

Rabe S, Reichwald J, Ammaturo D, de Strooper B, Saftig P, Neumann U, Staufenbiel M. Rabe S, et al. Among authors: staufenbiel m. J Neurochem. 2011 Oct;119(1):231-9. doi: 10.1111/j.1471-4159.2011.07412.x. Epub 2011 Sep 1. J Neurochem. 2011. PMID: 21812781 Free article.

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