Gellman SH - Search Results

1

High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL.

Lee EF, Sadowsky JD, Smith BJ, Czabotar PE, Peterson-Kaufman KJ, Colman PM, Gellman SH, Fairlie WD. Lee EF, et al. Among authors: gellman sh. Angew Chem Int Ed Engl. 2009;48(24):4318-22. doi: 10.1002/anie.200805761. Angew Chem Int Ed Engl. 2009. PMID: 19229915 Free PMC article.

2

Molecular architecture with functionalized beta-peptide helices.

Brückner AM, Chakraborty P, Gellman SH, Diederichsen U. Brückner AM, et al. Among authors: gellman sh. Angew Chem Int Ed Engl. 2003 Sep 22;42(36):4395-9. doi: 10.1002/anie.200351871. Angew Chem Int Ed Engl. 2003. PMID: 14502721 No abstract available.

3

Two helical conformations from a single foldamer backbone: "split personality" in short alpha/beta-peptides.

Hayen A, Schmitt MA, Ngassa FN, Thomasson KA, Gellman SH. Hayen A, et al. Among authors: gellman sh. Angew Chem Int Ed Engl. 2004 Jan 16;43(4):505-10. doi: 10.1002/anie.200352125. Angew Chem Int Ed Engl. 2004. PMID: 14735547 No abstract available.

4

Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition.

Sadowsky JD, Schmitt MA, Lee HS, Umezawa N, Wang S, Tomita Y, Gellman SH. Sadowsky JD, et al. Among authors: gellman sh. J Am Chem Soc. 2005 Aug 31;127(34):11966-8. doi: 10.1021/ja053678t. J Am Chem Soc. 2005. PMID: 16117535

5

Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation.

Murray JK, Farooqi B, Sadowsky JD, Scalf M, Freund WA, Smith LM, Chen J, Gellman SH. Murray JK, et al. Among authors: gellman sh. J Am Chem Soc. 2005 Sep 28;127(38):13271-80. doi: 10.1021/ja052733v. J Am Chem Soc. 2005. PMID: 16173757

6

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions.

Sadowsky JD, Fairlie WD, Hadley EB, Lee HS, Umezawa N, Nikolovska-Coleska Z, Wang S, Huang DC, Tomita Y, Gellman SH. Sadowsky JD, et al. Among authors: gellman sh. J Am Chem Soc. 2007 Jan 10;129(1):139-54. doi: 10.1021/ja0662523. J Am Chem Soc. 2007. PMID: 17199293

7

Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL.

Sadowsky JD, Murray JK, Tomita Y, Gellman SH. Sadowsky JD, et al. Among authors: gellman sh. Chembiochem. 2007 May 25;8(8):903-16. doi: 10.1002/cbic.200600546. Chembiochem. 2007. PMID: 17503422

8

H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding.

Tang L, Hopper ED, Tong Y, Sadowsky JD, Peterson KJ, Gellman SH, Fitzgerald MC. Tang L, et al. Among authors: gellman sh. Anal Chem. 2007 Aug 1;79(15):5869-77. doi: 10.1021/ac0700777. Epub 2007 Jun 21. Anal Chem. 2007. PMID: 17580981

9

Exploration of structure--activity relationships among foldamer ligands for a specific protein binding site via parallel and split-and-mix library synthesis.

Murray JK, Sadowsky JD, Scalf M, Smith LM, Tomita Y, Gellman SH. Murray JK, et al. Among authors: gellman sh. J Comb Chem. 2008 Mar-Apr;10(2):204-15. doi: 10.1021/cc700153z. Epub 2008 Feb 15. J Comb Chem. 2008. PMID: 18275161

10

Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains.

Horne WS, Boersma MD, Windsor MA, Gellman SH. Horne WS, et al. Among authors: gellman sh. Angew Chem Int Ed Engl. 2008;47(15):2853-6. doi: 10.1002/anie.200705315. Angew Chem Int Ed Engl. 2008. PMID: 18330876 Free PMC article. No abstract available.

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