Pasternak A - Search Results

1

Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.

Kothandaraman S, Donnely KL, Butora G, Jiao R, Pasternak A, Morriello GJ, Goble SD, Zhou C, Mills SG, Maccoss M, Vicario PP, Ayala JM, Demartino JA, Struthers M, Cascieri MA, Yang L. Kothandaraman S, et al. Among authors: pasternak a. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1830-4. doi: 10.1016/j.bmcl.2008.12.050. Epub 2008 Dec 24. Bioorg Med Chem Lett. 2009. PMID: 19237282

2

Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.

Yang L, Butora G, Jiao RX, Pasternak A, Zhou C, Parsons WH, Mills SG, Vicario PP, Ayala JM, Cascieri MA, MacCoss M. Yang L, et al. Among authors: pasternak a. J Med Chem. 2007 May 31;50(11):2609-11. doi: 10.1021/jm070166b. Epub 2007 Apr 27. J Med Chem. 2007. PMID: 17461566

3

Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.

Yang L, Zhou C, Guo L, Morriello G, Butora G, Pasternak A, Parsons WH, Mills SG, MacCoss M, Vicario PP, Zweerink H, Ayala JM, Goyal S, Hanlon WA, Cascieri MA, Springer MS. Yang L, et al. Among authors: pasternak a. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3735-9. doi: 10.1016/j.bmcl.2006.04.045. Epub 2006 May 15. Bioorg Med Chem Lett. 2006. PMID: 16698264

4

4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.

Butora G, Morriello GJ, Kothandaraman S, Guiadeen D, Pasternak A, Parsons WH, MacCoss M, Vicario PP, Cascieri MA, Yang L. Butora G, et al. Among authors: pasternak a. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4715-22. doi: 10.1016/j.bmcl.2006.07.011. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870431

5

Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists.

Pasternak A, Marino D, Vicario PP, Ayala JM, Cascierri MA, Parsons W, Mills SG, Maccoss M, Yang L. Pasternak A, et al. J Med Chem. 2006 Aug 10;49(16):4801-4. doi: 10.1021/jm060439n. J Med Chem. 2006. PMID: 16884289

6

Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists.

Pasternak A, Goble SD, Vicario PP, Di Salvo J, Ayala JM, Struthers M, DeMartino JA, Mills SG, Yang L. Pasternak A, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):994-8. doi: 10.1016/j.bmcl.2007.12.029. Epub 2007 Dec 27. Bioorg Med Chem Lett. 2008. PMID: 18164199

7

Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists.

Pasternak A, Goble SD, Doss GA, Tsou NN, Butora G, Vicario PP, Ayala JM, Struthers M, Demartino JA, Mills SG, Yang L. Pasternak A, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1374-7. doi: 10.1016/j.bmcl.2008.01.016. Epub 2008 Jan 9. Bioorg Med Chem Lett. 2008. PMID: 18215519

8

Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.

Pasternak A, Goble SD, deJesus RK, Hreniuk DL, Chung CC, Tota MR, Mazur P, Feighner SD, Howard AD, Mills SG, Yang L. Pasternak A, et al. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6237-40. doi: 10.1016/j.bmcl.2009.08.076. Epub 2009 Aug 26. Bioorg Med Chem Lett. 2009. PMID: 19767208

9

CCR2 antagonists.

Struthers M, Pasternak A. Struthers M, et al. Among authors: pasternak a. Curr Top Med Chem. 2010;10(13):1278-98. doi: 10.2174/156802610791561255. Curr Top Med Chem. 2010. PMID: 20536421 Review.

10

Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.

Tang H, Yan Y, Feng Z, de Jesus RK, Yang L, Levorse DA, Owens KA, Akiyama TE, Bergeron R, Castriota GA, Doebber TW, Ellsworth KP, Lassman ME, Li C, Wu MS, Zhang BB, Chapman KT, Mills SG, Berger JP, Pasternak A. Tang H, et al. Among authors: pasternak a. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6088-92. doi: 10.1016/j.bmcl.2010.08.047. Epub 2010 Aug 20. Bioorg Med Chem Lett. 2010. PMID: 20832306

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