Scheiber J - Search Results

1

Use of ligand based models for protein domains to predict novel molecular targets and applications to triage affinity chromatography data.

Bender A, Mikhailov D, Glick M, Scheiber J, Davies JW, Cleaver S, Marshall S, Tallarico JA, Harrington E, Cornella-Taracido I, Jenkins JL. Bender A, et al. Among authors: scheiber j. J Proteome Res. 2009 May;8(5):2575-85. doi: 10.1021/pr900107z. J Proteome Res. 2009. PMID: 19271732

2

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure.

Bender A, Scheiber J, Glick M, Davies JW, Azzaoui K, Hamon J, Urban L, Whitebread S, Jenkins JL. Bender A, et al. Among authors: scheiber j. ChemMedChem. 2007 Jun;2(6):861-73. doi: 10.1002/cmdc.200700026. ChemMedChem. 2007. PMID: 17477341

3

Understanding false positives in reporter gene assays: in silico chemogenomics approaches to prioritize cell-based HTS data.

Crisman TJ, Parker CN, Jenkins JL, Scheiber J, Thoma M, Kang ZB, Kim R, Bender A, Nettles JH, Davies JW, Glick M. Crisman TJ, et al. Among authors: scheiber j. J Chem Inf Model. 2007 Jul-Aug;47(4):1319-27. doi: 10.1021/ci6005504. Epub 2007 Jul 4. J Chem Inf Model. 2007. PMID: 17608469

4

"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.

Crisman TJ, Bender A, Milik M, Jenkins JL, Scheiber J, Sukuru SC, Fejzo J, Hommel U, Davies JW, Glick M. Crisman TJ, et al. Among authors: scheiber j. J Med Chem. 2008 Apr 24;51(8):2481-91. doi: 10.1021/jm701314u. Epub 2008 Mar 22. J Med Chem. 2008. PMID: 18357974

5

Which aspects of HTS are empirically correlated with downstream success?

Bender A, Bojanic D, Davies JW, Crisman TJ, Mikhailov D, Scheiber J, Jenkins JL, Deng Z, Hill WA, Popov M, Jacoby E, Glick M. Bender A, et al. Among authors: scheiber j. Curr Opin Drug Discov Devel. 2008 May;11(3):327-37. Curr Opin Drug Discov Devel. 2008. PMID: 18428086 Review.

6

How similar are similarity searching methods? A principal component analysis of molecular descriptor space.

Bender A, Jenkins JL, Scheiber J, Sukuru SC, Glick M, Davies JW. Bender A, et al. Among authors: scheiber j. J Chem Inf Model. 2009 Jan;49(1):108-19. doi: 10.1021/ci800249s. J Chem Inf Model. 2009. PMID: 19123924

7

Mapping adverse drug reactions in chemical space.

Scheiber J, Jenkins JL, Sukuru SC, Bender A, Mikhailov D, Milik M, Azzaoui K, Whitebread S, Hamon J, Urban L, Glick M, Davies JW. Scheiber J, et al. J Med Chem. 2009 May 14;52(9):3103-7. doi: 10.1021/jm801546k. J Med Chem. 2009. PMID: 19378990

8

Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.

Scheiber J, Chen B, Milik M, Sukuru SC, Bender A, Mikhailov D, Whitebread S, Hamon J, Azzaoui K, Urban L, Glick M, Davies JW, Jenkins JL. Scheiber J, et al. J Chem Inf Model. 2009 Feb;49(2):308-17. doi: 10.1021/ci800344p. J Chem Inf Model. 2009. PMID: 19434832

9

Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity.

Sukuru SC, Jenkins JL, Beckwith RE, Scheiber J, Bender A, Mikhailov D, Davies JW, Glick M. Sukuru SC, et al. Among authors: scheiber j. J Biomol Screen. 2009 Jul;14(6):690-9. doi: 10.1177/1087057109335678. Epub 2009 Jun 16. J Biomol Screen. 2009. PMID: 19531667

10

Chemogenomic analysis of safety profiling data.

Scheiber J, Jenkins JL. Scheiber J, et al. Methods Mol Biol. 2009;575:207-23. doi: 10.1007/978-1-60761-274-2_9. Methods Mol Biol. 2009. PMID: 19727617

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