Higgins L - Search Results

1

Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart.

Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME. Singh MV, et al. Among authors: higgins l. J Clin Invest. 2009 Apr;119(4):986-96. doi: 10.1172/JCI35814. Epub 2009 Mar 9. J Clin Invest. 2009. PMID: 19273909 Free PMC article.

2

Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease.

Anderson ME, Higgins LS, Schulman H. Anderson ME, et al. Nat Clin Pract Cardiovasc Med. 2006 Aug;3(8):437-45. doi: 10.1038/ncpcardio0585. Nat Clin Pract Cardiovasc Med. 2006. PMID: 16874356 Review.

3

Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression.

Kapoun AM, Gaspar NJ, Wang Y, Damm D, Liu YW, O'young G, Quon D, Lam A, Munson K, Tran TT, Ma JY, Murphy A, Dugar S, Chakravarty S, Protter AA, Wen FQ, Liu X, Rennard SI, Higgins LS. Kapoun AM, et al. Mol Pharmacol. 2006 Aug;70(2):518-31. doi: 10.1124/mol.105.021600. Epub 2006 May 17. Mol Pharmacol. 2006. PMID: 16707625

4

Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment.

Medicherla S, Li L, Ma JY, Kapoun AM, Gaspar NJ, Liu YW, Mangadu R, O'Young G, Protter AA, Schreiner GF, Wong DH, Higgins LS. Medicherla S, et al. Among authors: higgins ls. Anticancer Res. 2007 Nov-Dec;27(6B):4149-57. Anticancer Res. 2007. PMID: 18229422 Free article.

5

Role of p38 mitogen-activated protein kinase in ozone-induced airway hyperresponsiveness and inflammation.

Williams AS, Issa R, Durham A, Leung SY, Kapoun A, Medicherla S, Higgins LS, Adcock IM, Chung KF. Williams AS, et al. Eur J Pharmacol. 2008 Dec 14;600(1-3):117-22. doi: 10.1016/j.ejphar.2008.09.031. Epub 2008 Sep 30. Eur J Pharmacol. 2008. PMID: 18926814

6

Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor.

Bonniaud P, Margetts PJ, Kolb M, Schroeder JA, Kapoun AM, Damm D, Murphy A, Chakravarty S, Dugar S, Higgins L, Protter AA, Gauldie J. Bonniaud P, et al. Among authors: higgins l. Am J Respir Crit Care Med. 2005 Apr 15;171(8):889-98. doi: 10.1164/rccm.200405-612OC. Epub 2004 Nov 24. Am J Respir Crit Care Med. 2005. PMID: 15563636

7

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.

Nguyen AN, Stebbins EG, Henson M, O'Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS. Nguyen AN, et al. Exp Cell Res. 2006 Jun 10;312(10):1909-23. doi: 10.1016/j.yexcr.2006.02.026. Epub 2006 Apr 4. Exp Cell Res. 2006. PMID: 16600214

8

Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.

Gaspar NJ, Li L, Kapoun AM, Medicherla S, Reddy M, Li G, O'Young G, Quon D, Henson M, Damm DL, Muiru GT, Murphy A, Higgins LS, Chakravarty S, Wong DH. Gaspar NJ, et al. Among authors: higgins ls. Mol Pharmacol. 2007 Jul;72(1):152-61. doi: 10.1124/mol.106.029025. Epub 2007 Mar 30. Mol Pharmacol. 2007. PMID: 17400764

9

p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation.

Medicherla S, Fitzgerald MF, Spicer D, Woodman P, Ma JY, Kapoun AM, Chakravarty S, Dugar S, Protter AA, Higgins LS. Medicherla S, et al. J Pharmacol Exp Ther. 2008 Mar;324(3):921-9. doi: 10.1124/jpet.107.127092. Epub 2007 Dec 4. J Pharmacol Exp Ther. 2008. PMID: 18056868

10

p38 Inhibition attenuates the pro-inflammatory response to C-reactive protein by human peripheral blood mononuclear cells.

Lim MY, Wang H, Kapoun AM, O'connell M, O'Young G, Brauer HA, Luedtke GR, Chakravarty S, Dugar S, Schreiner GS, Protter AA, Higgins LS. Lim MY, et al. J Mol Cell Cardiol. 2004 Dec;37(6):1111-4. doi: 10.1016/j.yjmcc.2004.09.015. J Mol Cell Cardiol. 2004. PMID: 15572041

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