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Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein.
Oerlemans R, Franke NE, Assaraf YG, Cloos J, van Zantwijk I, Berkers CR, Scheffer GL, Debipersad K, Vojtekova K, Lemos C, van der Heijden JW, Ylstra B, Peters GJ, Kaspers GL, Dijkmans BA, Scheper RJ, Jansen G. Oerlemans R, et al. Blood. 2008 Sep 15;112(6):2489-99. doi: 10.1182/blood-2007-08-104950. Epub 2008 Jun 18. Blood. 2008. PMID: 18565852 Free article.
Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis.
Verbrugge SE, Assaraf YG, Dijkmans BA, Scheffer GL, Al M, den Uyl D, Oerlemans R, Chan ET, Kirk CJ, Peters GJ, van der Heijden JW, de Gruijl TD, Scheper RJ, Jansen G. Verbrugge SE, et al. Among authors: oerlemans r. J Pharmacol Exp Ther. 2012 Apr;341(1):174-82. doi: 10.1124/jpet.111.187542. Epub 2012 Jan 10. J Pharmacol Exp Ther. 2012. PMID: 22235146 Clinical Trial.
Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells.
de Bruin M, Peters GJ, Oerlemans R, Assaraf YG, Masterson AJ, Adema AD, Dijkmans BA, Pinedo HM, Jansen G. de Bruin M, et al. Among authors: oerlemans r. Mol Pharmacol. 2004 Oct;66(4):1054-60. doi: 10.1124/mol.104.000315. Epub 2004 Jul 21. Mol Pharmacol. 2004. PMID: 15269287
Sulfasalazine sensitises human monocytic/macrophage cells for glucocorticoids by upregulation of glucocorticoid receptor alpha and glucocorticoid induced apoptosis.
Oerlemans R, Vink J, Dijkmans BA, Assaraf YG, van Miltenburg M, van der Heijden J, Ifergan I, Lems WF, Scheper RJ, Kaspers GJ, Cloos J, Jansen G. Oerlemans R, et al. Ann Rheum Dis. 2007 Oct;66(10):1289-95. doi: 10.1136/ard.2006.060509. Epub 2007 Jan 31. Ann Rheum Dis. 2007. PMID: 17267514 Free PMC article.
Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide.
van der Heijden JW, Oerlemans R, Tak PP, Assaraf YG, Kraan MC, Scheffer GL, van der Laken CJ, Lems WF, Scheper RJ, Dijkmans BA, Jansen G. van der Heijden JW, et al. Among authors: oerlemans r. Arthritis Rheum. 2009 Mar;60(3):669-77. doi: 10.1002/art.24354. Arthritis Rheum. 2009. PMID: 19248091 Free article.
36 results