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Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors.
Maione S, Bisogno T, de Novellis V, Palazzo E, Cristino L, Valenti M, Petrosino S, Guglielmotti V, Rossi F, Di Marzo V. Maione S, et al. J Pharmacol Exp Ther. 2006 Mar;316(3):969-82. doi: 10.1124/jpet.105.093286. Epub 2005 Nov 11. J Pharmacol Exp Ther. 2006. PMID: 16284279
In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands.
Cascio MG, Bisogno T, Palazzo E, Thomas A, van der Stelt M, Brizzi A, de Novellis V, Marabese I, Ross R, van de Doelen T, Brizzi V, Pertwee R, Maione S, Di Marzo V. Cascio MG, et al. Among authors: maione s. Br J Pharmacol. 2006 Oct;149(4):431-40. doi: 10.1038/sj.bjp.0706888. Epub 2006 Sep 4. Br J Pharmacol. 2006. PMID: 16953186 Free PMC article.
Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception.
Marabese I, Rossi F, Palazzo E, de Novellis V, Starowicz K, Cristino L, Vita D, Gatta L, Guida F, Di Marzo V, Rossi F, Maione S. Marabese I, et al. Among authors: maione s. J Neurophysiol. 2007 Jul;98(1):43-53. doi: 10.1152/jn.00356.2007. Epub 2007 May 16. J Neurophysiol. 2007. PMID: 17507496 Free article.
The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats.
de Novellis V, Palazzo E, Rossi F, De Petrocellis L, Petrosino S, Guida F, Luongo L, Migliozzi A, Cristino L, Marabese I, Starowicz K, Di Marzo V, Maione S; Endocannabinoid Research Group. de Novellis V, et al. Among authors: maione s. Neuropharmacology. 2008 Dec;55(7):1105-13. doi: 10.1016/j.neuropharm.2008.06.023. Epub 2008 Jun 20. Neuropharmacology. 2008. PMID: 18616956
367 results