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Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.
Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, Galavotti S, Young KW, Selmi T, Yacobi R, Van Etten RA, Donato N, Hunter A, Dinsdale D, Tirrò E, Vigneri P, Nicotera P, Dyer MJ, Holyoake T, Salomoni P, Calabretta B. Bellodi C, et al. Among authors: helgason gv. J Clin Invest. 2009 May;119(5):1109-23. doi: 10.1172/JCI35660. Epub 2009 Apr 13. J Clin Invest. 2009. PMID: 19363292 Free PMC article.
Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells.
Myssina S, Helgason GV, Serrels A, Jørgensen HG, Bhatia R, Modi H, Baird JW, Mountford JC, Hamilton A, Schemionek M, Koschmieder S, Brunton VG, Holyoake TL. Myssina S, et al. Among authors: helgason gv. Exp Hematol. 2009 Feb;37(2):206-14. doi: 10.1016/j.exphem.2008.10.013. Epub 2008 Dec 18. Exp Hematol. 2009. PMID: 19100678 Free article.
FOXO transcription factor activity is partially retained in quiescent CML stem cells and induced by tyrosine kinase inhibitors in CML progenitor cells.
Pellicano F, Cilloni D, Helgason GV, Messa F, Panuzzo C, Arruga F, Bracco E, Allan E, Huntly BJ, Holyoake TL, Saglio G. Pellicano F, et al. Among authors: helgason gv. Blood. 2009 Dec 1. doi: 10.1182/blood-2009-06-226621. Epub 2009 Dec 1. Blood. 2009. Retraction in: Blood. 2010 Apr 8;115(14):2983. doi: 10.1182/blood-2010-03-273375 PMID: 19965658 Retracted.
Targeting chronic myeloid leukemia stem cells.
Helgason GV, Young GA, Holyoake TL. Helgason GV, et al. Curr Hematol Malig Rep. 2010 Apr;5(2):81-7. doi: 10.1007/s11899-010-0043-0. Curr Hematol Malig Rep. 2010. PMID: 20425400 Review.
45 results