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Page 1
O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib.
Watson AJ, Middleton MR, McGown G, Thorncroft M, Ranson M, Hersey P, McArthur G, Davis ID, Thomson D, Beith J, Haydon A, Kefford R, Lorigan P, Mortimer P, Sabharwal A, Hayward O, Margison GP. Watson AJ, et al. Among authors: thorncroft m. Br J Cancer. 2009 Apr 21;100(8):1250-6. doi: 10.1038/sj.bjc.6605015. Br J Cancer. 2009. PMID: 19367283 Free PMC article. Clinical Trial.
Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib.
Watson AJ, Sabharwal A, Thorncroft M, McGown G, Kerr R, Bojanic S, Soonawalla Z, King A, Miller A, Waller S, Leung H, Margison GP, Middleton MR. Watson AJ, et al. Among authors: thorncroft m. Clin Cancer Res. 2010 Jan 15;16(2):743-9. doi: 10.1158/1078-0432.CCR-09-1389. Epub 2010 Jan 12. Clin Cancer Res. 2010. PMID: 20068091 Free PMC article. Clinical Trial.
Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.
Plummer ER, Middleton MR, Jones C, Olsen A, Hickson I, McHugh P, Margison GP, McGown G, Thorncroft M, Watson AJ, Boddy AV, Calvert AH, Harris AL, Newell DR, Curtin NJ. Plummer ER, et al. Among authors: thorncroft m. Clin Cancer Res. 2005 May 1;11(9):3402-9. doi: 10.1158/1078-0432.CCR-04-2353. Clin Cancer Res. 2005. PMID: 15867241 Free article. Clinical Trial.
A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours.
Khan OA, Gore M, Lorigan P, Stone J, Greystoke A, Burke W, Carmichael J, Watson AJ, McGown G, Thorncroft M, Margison GP, Califano R, Larkin J, Wellman S, Middleton MR. Khan OA, et al. Among authors: thorncroft m. Br J Cancer. 2011 Mar 1;104(5):750-5. doi: 10.1038/bjc.2011.8. Epub 2011 Feb 15. Br J Cancer. 2011. PMID: 21326243 Free PMC article. Clinical Trial.
Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells.
Margison GP, Heighway J, Pearson S, McGown G, Thorncroft MR, Watson AJ, Harrison KL, Lewis SJ, Rohde K, Barber PV, O'Donnell P, Povey AC, Santibáñez-Koref MF. Margison GP, et al. Carcinogenesis. 2005 Aug;26(8):1473-80. doi: 10.1093/carcin/bgi087. Epub 2005 Apr 14. Carcinogenesis. 2005. PMID: 15831531
Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase.
Crosbie PA, McGown G, Thorncroft MR, O'Donnell PN, Barber PV, Lewis SJ, Harrison KL, Agius RM, Santibáñez-Koref MF, Margison GP, Povey AC. Crosbie PA, et al. Among authors: thorncroft mr. Int J Cancer. 2008 Feb 15;122(4):791-5. doi: 10.1002/ijc.23059. Int J Cancer. 2008. PMID: 17957803
Allelic imbalance of chromosome 6q in ovarian tumours.
Orphanos V, McGown G, Hey Y, Thorncroft M, Santibanez-Koref M, Russell SE, Hickey I, Atkinson RJ, Boyle JM. Orphanos V, et al. Among authors: thorncroft m. Br J Cancer. 1995 Apr;71(4):666-9. doi: 10.1038/bjc.1995.132. Br J Cancer. 1995. PMID: 7710926 Free PMC article.
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
Latypov VF, Tubbs JL, Watson AJ, Marriott AS, McGown G, Thorncroft M, Wilkinson OJ, Senthong P, Butt A, Arvai AS, Millington CL, Povey AC, Williams DM, Santibanez-Koref MF, Tainer JA, Margison GP. Latypov VF, et al. Among authors: thorncroft m. Mol Cell. 2012 Jul 13;47(1):50-60. doi: 10.1016/j.molcel.2012.04.028. Epub 2012 May 31. Mol Cell. 2012. PMID: 22658721 Free PMC article.
24 results