Hamon J - Search Results

1

Mapping adverse drug reactions in chemical space.

Scheiber J, Jenkins JL, Sukuru SC, Bender A, Mikhailov D, Milik M, Azzaoui K, Whitebread S, Hamon J, Urban L, Glick M, Davies JW. Scheiber J, et al. Among authors: hamon j. J Med Chem. 2009 May 14;52(9):3103-7. doi: 10.1021/jm801546k. J Med Chem. 2009. PMID: 19378990

2

Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development.

Whitebread S, Hamon J, Bojanic D, Urban L. Whitebread S, et al. Among authors: hamon j. Drug Discov Today. 2005 Nov 1;10(21):1421-33. doi: 10.1016/S1359-6446(05)03632-9. Drug Discov Today. 2005. PMID: 16243262 Review.

3

High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis.

Faller B, Wang J, Zimmerlin A, Bell L, Hamon J, Whitebread S, Azzaoui K, Bojanic D, Urban L. Faller B, et al. Among authors: hamon j. Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):823-33. doi: 10.1517/17425255.2.6.823. Expert Opin Drug Metab Toxicol. 2006. PMID: 17125403 Review.

4

Clustering and rule-based classifications of chemical structures evaluated in the biological activity space.

Schuffenhauer A, Brown N, Ertl P, Jenkins JL, Selzer P, Hamon J. Schuffenhauer A, et al. Among authors: hamon j. J Chem Inf Model. 2007 Mar-Apr;47(2):325-36. doi: 10.1021/ci6004004. Epub 2007 Feb 8. J Chem Inf Model. 2007. PMID: 17286395

5

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure.

Bender A, Scheiber J, Glick M, Davies JW, Azzaoui K, Hamon J, Urban L, Whitebread S, Jenkins JL. Bender A, et al. Among authors: hamon j. ChemMedChem. 2007 Jun;2(6):861-73. doi: 10.1002/cmdc.200700026. ChemMedChem. 2007. PMID: 17477341

6

Modeling promiscuity based on in vitro safety pharmacology profiling data.

Azzaoui K, Hamon J, Faller B, Whitebread S, Jacoby E, Bender A, Jenkins JL, Urban L. Azzaoui K, et al. Among authors: hamon j. ChemMedChem. 2007 Jun;2(6):874-80. doi: 10.1002/cmdc.200700036. ChemMedChem. 2007. PMID: 17492703

7

Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.

Scheiber J, Chen B, Milik M, Sukuru SC, Bender A, Mikhailov D, Whitebread S, Hamon J, Azzaoui K, Urban L, Glick M, Davies JW, Jenkins JL. Scheiber J, et al. Among authors: hamon j. J Chem Inf Model. 2009 Feb;49(2):308-17. doi: 10.1021/ci800344p. J Chem Inf Model. 2009. PMID: 19434832

8

In vitro safety pharmacology profiling: what else beyond hERG?

Hamon J, Whitebread S, Techer-Etienne V, Le Coq H, Azzaoui K, Urban L. Hamon J, et al. Future Med Chem. 2009 Jul;1(4):645-65. doi: 10.4155/fmc.09.51. Future Med Chem. 2009. PMID: 21426031 Review.

9

Large-scale prediction and testing of drug activity on side-effect targets.

Lounkine E, Keiser MJ, Whitebread S, Mikhailov D, Hamon J, Jenkins JL, Lavan P, Weber E, Doak AK, Côté S, Shoichet BK, Urban L. Lounkine E, et al. Among authors: hamon j. Nature. 2012 Jun 10;486(7403):361-7. doi: 10.1038/nature11159. Nature. 2012. PMID: 22722194 Free PMC article.

10

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling.

Bowes J, Brown AJ, Hamon J, Jarolimek W, Sridhar A, Waldron G, Whitebread S. Bowes J, et al. Among authors: hamon j. Nat Rev Drug Discov. 2012 Dec;11(12):909-22. doi: 10.1038/nrd3845. Nat Rev Drug Discov. 2012. PMID: 23197038 Review.

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