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Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.
Brähler S, Kaistha A, Schmidt VJ, Wölfle SE, Busch C, Kaistha BP, Kacik M, Hasenau AL, Grgic I, Si H, Bond CT, Adelman JP, Wulff H, de Wit C, Hoyer J, Köhler R. Brähler S, et al. Among authors: wolfle se. Circulation. 2009 May 5;119(17):2323-32. doi: 10.1161/CIRCULATIONAHA.108.846634. Epub 2009 Apr 20. Circulation. 2009. PMID: 19380617 Free article.
Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+ channel.
Si H, Heyken WT, Wölfle SE, Tysiac M, Schubert R, Grgic I, Vilianovich L, Giebing G, Maier T, Gross V, Bader M, de Wit C, Hoyer J, Köhler R. Si H, et al. Among authors: wolfle se. Circ Res. 2006 Sep 1;99(5):537-44. doi: 10.1161/01.RES.0000238377.08219.0c. Epub 2006 Jul 27. Circ Res. 2006. PMID: 16873714
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