Mileni M - Search Results

1

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.

Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, Swaney S, Van Becelaere K, Stevens RC, Cravatt BF. Ahn K, et al. Among authors: mileni m. Chem Biol. 2009 Apr 24;16(4):411-20. doi: 10.1016/j.chembiol.2009.02.013. Chem Biol. 2009. PMID: 19389627 Free PMC article.

2

Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.

Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, Stevens RC. Slaymaker IM, et al. Among authors: mileni m. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5847-50. doi: 10.1016/j.bmcl.2008.06.086. Epub 2008 Jun 28. Bioorg Med Chem Lett. 2008. PMID: 18644727 Free PMC article.

3

Structure-guided inhibitor design for human FAAH by interspecies active site conversion.

Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, Stevens RC. Mileni M, et al. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12820-4. doi: 10.1073/pnas.0806121105. Epub 2008 Aug 27. Proc Natl Acad Sci U S A. 2008. PMID: 18753625 Free PMC article.

4

X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.

Mileni M, Garfunkle J, Ezzili C, Kimball FS, Cravatt BF, Stevens RC, Boger DL. Mileni M, et al. J Med Chem. 2010 Jan 14;53(1):230-40. doi: 10.1021/jm9012196. J Med Chem. 2010. PMID: 19924997 Free PMC article.

5

Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation.

Mileni M, Kamtekar S, Wood DC, Benson TE, Cravatt BF, Stevens RC. Mileni M, et al. J Mol Biol. 2010 Jul 23;400(4):743-54. doi: 10.1016/j.jmb.2010.05.034. Epub 2010 May 21. J Mol Biol. 2010. PMID: 20493882 Free PMC article.

6

Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase.

Mileni M, Garfunkle J, Ezzili C, Cravatt BF, Stevens RC, Boger DL. Mileni M, et al. J Am Chem Soc. 2011 Mar 23;133(11):4092-100. doi: 10.1021/ja110877y. Epub 2011 Feb 28. J Am Chem Soc. 2011. PMID: 21355555 Free PMC article.

7

Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.

Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. Ezzili C, et al. Among authors: mileni m. J Med Chem. 2011 Apr 28;54(8):2805-22. doi: 10.1021/jm101597x. Epub 2011 Mar 23. J Med Chem. 2011. PMID: 21428410 Free PMC article.

8

Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.

Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC. Mileni M, et al. J Am Chem Soc. 2009 Aug 5;131(30):10497-506. doi: 10.1021/ja902694n. J Am Chem Soc. 2009. PMID: 19722626 Free PMC article.

9

The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes.

Skjevik AA, Mileni M, Baumann A, Halskau O, Teigen K, Stevens RC, Martinez A. Skjevik AA, et al. Among authors: mileni m. J Mol Biol. 2014 Jan 9;426(1):150-68. doi: 10.1016/j.jmb.2013.09.012. Epub 2013 Sep 17. J Mol Biol. 2014. PMID: 24055376 Free PMC article.

10

Microscale fluorescent thermal stability assay for membrane proteins.

Alexandrov AI, Mileni M, Chien EY, Hanson MA, Stevens RC. Alexandrov AI, et al. Among authors: mileni m. Structure. 2008 Mar;16(3):351-9. doi: 10.1016/j.str.2008.02.004. Structure. 2008. PMID: 18334210 Free article.

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