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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.
Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, Mueller M, Fumagalli S, Kozma SC, Thomas G. Pende M, et al. Among authors: kozma sc. Mol Cell Biol. 2004 Apr;24(8):3112-24. doi: 10.1128/MCB.24.8.3112-3124.2004. Mol Cell Biol. 2004. PMID: 15060135 Free PMC article.
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ. Selman C, et al. Among authors: kozma sc. Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221. Science. 2009. PMID: 19797661 Free PMC article.
A liaison between mTOR signaling, ribosome biogenesis and cancer.
Gentilella A, Kozma SC, Thomas G. Gentilella A, et al. Among authors: kozma sc. Biochim Biophys Acta. 2015 Jul;1849(7):812-20. doi: 10.1016/j.bbagrm.2015.02.005. Epub 2015 Feb 28. Biochim Biophys Acta. 2015. PMID: 25735853 Free PMC article. Review.
98 results