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Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R. Zimmermann R, et al. Among authors: zechner r. Science. 2004 Nov 19;306(5700):1383-6. doi: 10.1126/science.1100747. Science. 2004. PMID: 15550674
Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis.
Reid BN, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, Blaner WS, Goldberg IJ, Schwabe RF, Chua SC Jr, Huang LS. Reid BN, et al. Among authors: zechner r. J Biol Chem. 2008 May 9;283(19):13087-99. doi: 10.1074/jbc.M800533200. Epub 2008 Mar 12. J Biol Chem. 2008. PMID: 18337240 Free PMC article.
Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids.
Schoiswohl G, Schweiger M, Schreiber R, Gorkiewicz G, Preiss-Landl K, Taschler U, Zierler KA, Radner FP, Eichmann TO, Kienesberger PC, Eder S, Lass A, Haemmerle G, Alsted TJ, Kiens B, Hoefler G, Zechner R, Zimmermann R. Schoiswohl G, et al. Among authors: zechner r. J Lipid Res. 2010 Mar;51(3):490-9. doi: 10.1194/jlr.M001073. Epub 2009 Nov 25. J Lipid Res. 2010. PMID: 19965578 Free PMC article.
Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).
Radner FP, Streith IE, Schoiswohl G, Schweiger M, Kumari M, Eichmann TO, Rechberger G, Koefeler HC, Eder S, Schauer S, Theussl HC, Preiss-Landl K, Lass A, Zimmermann R, Hoefler G, Zechner R, Haemmerle G. Radner FP, et al. Among authors: zechner r. J Biol Chem. 2010 Mar 5;285(10):7300-11. doi: 10.1074/jbc.M109.081877. Epub 2009 Dec 18. J Biol Chem. 2010. PMID: 20023287 Free PMC article.
The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase.
Gruber A, Cornaciu I, Lass A, Schweiger M, Poeschl M, Eder C, Kumari M, Schoiswohl G, Wolinski H, Kohlwein SD, Zechner R, Zimmermann R, Oberer M. Gruber A, et al. Among authors: zechner r. J Biol Chem. 2010 Apr 16;285(16):12289-98. doi: 10.1074/jbc.M109.064469. Epub 2010 Feb 17. J Biol Chem. 2010. PMID: 20164531 Free PMC article.
249 results