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Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein.
Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W, Colvin SC, Rhodes SJ, Shou W, Zhang ZY. Dong Y, et al. Among authors: chen h. J Biol Chem. 2012 Sep 14;287(38):32172-9. doi: 10.1074/jbc.M112.393462. Epub 2012 Jul 12. J Biol Chem. 2012. PMID: 22791713 Free PMC article.
Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function.
Shen WH, Chen Z, Shi S, Chen H, Zhu W, Penner A, Bu G, Li W, Boyle DW, Rubart M, Field LJ, Abraham R, Liechty EA, Shou W. Shen WH, et al. Among authors: chen z, chen h. J Biol Chem. 2008 May 16;283(20):13842-9. doi: 10.1074/jbc.M801510200. Epub 2008 Mar 7. J Biol Chem. 2008. PMID: 18326485 Free PMC article.
Smad7 is required for the development and function of the heart.
Chen Q, Chen H, Zheng D, Kuang C, Fang H, Zou B, Zhu W, Bu G, Jin T, Wang Z, Zhang X, Chen J, Field LJ, Rubart M, Shou W, Chen Y. Chen Q, et al. Among authors: chen j, chen h, chen y. J Biol Chem. 2009 Jan 2;284(1):292-300. doi: 10.1074/jbc.M807233200. Epub 2008 Oct 24. J Biol Chem. 2009. PMID: 18952608 Free PMC article.
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