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Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.
Zheng W, Padia J, Urban DJ, Jadhav A, Goker-Alpan O, Simeonov A, Goldin E, Auld D, LaMarca ME, Inglese J, Austin CP, Sidransky E. Zheng W, et al. Among authors: sidransky e. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7. doi: 10.1073/pnas.0705637104. Epub 2007 Aug 1. Proc Natl Acad Sci U S A. 2007. PMID: 17670938 Free PMC article.
N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease.
Huang W, Zheng W, Urban DJ, Inglese J, Sidransky E, Austin CP, Thomas CJ. Huang W, et al. Among authors: sidransky e. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5783-9. doi: 10.1016/j.bmcl.2007.08.050. Epub 2007 Aug 28. Bioorg Med Chem Lett. 2007. PMID: 17827006 Free PMC article.
A new resorufin-based alpha-glucosidase assay for high-throughput screening.
Motabar O, Shi ZD, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. Motabar O, et al. Among authors: sidransky e. Anal Biochem. 2009 Jul 1;390(1):79-84. doi: 10.1016/j.ab.2009.04.010. Epub 2009 Apr 14. Anal Biochem. 2009. PMID: 19371716 Free PMC article.
Fabry disease - current treatment and new drug development.
Motabar O, Sidransky E, Goldin E, Zheng W. Motabar O, et al. Among authors: sidransky e. Curr Chem Genomics. 2010 Jul 23;4:50-6. doi: 10.2174/1875397301004010050. Curr Chem Genomics. 2010. PMID: 21127742 Free PMC article.
High throughput screening for inhibitors of alpha-galactosidase.
Motabar O, Liu K, Southall N, Marugan JJ, Goldin E, Sidransky E, Zheng W. Motabar O, et al. Among authors: sidransky e. Curr Chem Genomics. 2010 Dec 3;4:67-73. doi: 10.2174/1875397301004010067. Curr Chem Genomics. 2010. PMID: 21331308 Free PMC article.
296 results