YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis.
Collawn JF, Lai A, Domingo D, Fitch M, Hatton S, Trowbridge IS.
Collawn JF, et al.
J Biol Chem. 1993 Oct 15;268(29):21686-92.
J Biol Chem. 1993.
PMID: 8408022
Free article.
By functional analysis of mutant human transferrin receptors (TR) expressed in chicken embryo fibroblasts, we previously identified a tetrapeptide sequence, Y20TRF23, within the 61-residue cytoplasmic tail as the signal for high-efficiency endocytosis (Collawn, J. F …
By functional analysis of mutant human transferrin receptors (TR) expressed in chicken embryo fibroblasts, we previously identified a tetrap …