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Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff U, Prat A, Prozorovski T, Siffrin V, Paterka M, Herz J, Bendix I, Ifergan I, Schadock I, Mori MA, Van Horssen J, Schröter F, Smorodchenko A, Han MH, Bader M, Steinman L, Aktas O, Zipp F. Schulze-Topphoff U, et al. Among authors: ifergan i. Nat Med. 2009 Jul;15(7):788-93. doi: 10.1038/nm.1980. Epub 2009 Jun 28. Nat Med. 2009. PMID: 19561616 Free PMC article.
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.
Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonnière L, Bernard M, van Horssen J, de Vries HE, Charron F, Prat A. Alvarez JI, et al. Among authors: ifergan i. Science. 2011 Dec 23;334(6063):1727-31. doi: 10.1126/science.1206936. Epub 2011 Dec 1. Science. 2011. PMID: 22144466
Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system.
Larochelle C, Cayrol R, Kebir H, Alvarez JI, Lécuyer MA, Ifergan I, Viel É, Bourbonnière L, Beauseigle D, Terouz S, Hachehouche L, Gendron S, Poirier J, Jobin C, Duquette P, Flanagan K, Yednock T, Arbour N, Prat A. Larochelle C, et al. Among authors: ifergan i. Brain. 2012 Oct;135(Pt 10):2906-24. doi: 10.1093/brain/aws212. Epub 2012 Sep 13. Brain. 2012. PMID: 22975388
Targeting the GM-CSF receptor for the treatment of CNS autoimmunity.
Ifergan I, Davidson TS, Kebir H, Xu D, Palacios-Macapagal D, Cann J, Rodgers JM, Hunter ZN, Pittet CL, Beddow S, Jones CA, Prat A, Sleeman MA, Miller SD. Ifergan I, et al. J Autoimmun. 2017 Nov;84:1-11. doi: 10.1016/j.jaut.2017.06.005. Epub 2017 Jun 20. J Autoimmun. 2017. PMID: 28641926 Free PMC article.
58 results