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Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo.
Feisst C, Pergola C, Rakonjac M, Rossi A, Koeberle A, Dodt G, Hoffmann M, Hoernig C, Fischer L, Steinhilber D, Franke L, Schneider G, Rådmark O, Sautebin L, Werz O. Feisst C, et al. Among authors: schneider g. Cell Mol Life Sci. 2009 Aug;66(16):2759-71. doi: 10.1007/s00018-009-0078-3. Epub 2009 Jul 5. Cell Mol Life Sci. 2009. PMID: 19579006 Free PMC article.
Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells.
Werz O, Tretiakova I, Michel A, Ulke-Lemee A, Hörnig M, Franke L, Schneider G, Samuelsson B, Rådmark O, Steinhilber D. Werz O, et al. Among authors: schneider g. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13164-9. doi: 10.1073/pnas.0505991102. Epub 2005 Aug 31. Proc Natl Acad Sci U S A. 2005. PMID: 16135563 Free PMC article.
Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor.
Wisniewska JM, Rödl CB, Kahnt AS, Buscató El, Ulrich S, Tanrikulu Y, Achenbach J, Rörsch F, Grösch S, Schneider G, Cinatl J Jr, Proschak E, Steinhilber D, Hofmann B. Wisniewska JM, et al. Among authors: schneider g. Biochem Pharmacol. 2012 Jan 15;83(2):228-40. doi: 10.1016/j.bcp.2011.10.012. Epub 2011 Oct 18. Biochem Pharmacol. 2012. PMID: 22027220
Dimerization of human 5-lipoxygenase.
Häfner AK, Cernescu M, Hofmann B, Ermisch M, Hörnig M, Metzner J, Schneider G, Brutschy B, Steinhilber D. Häfner AK, et al. Among authors: schneider g. Biol Chem. 2011 Dec;392(12):1097-111. doi: 10.1515/BC.2011.200. Biol Chem. 2011. PMID: 22050225
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
Hanke T, Dehm F, Liening S, Popella SD, Maczewsky J, Pillong M, Kunze J, Weinigel C, Barz D, Kaiser A, Wurglics M, Lämmerhofer M, Schneider G, Sautebin L, Schubert-Zsilavecz M, Werz O. Hanke T, et al. Among authors: schneider g. J Med Chem. 2013 Nov 27;56(22):9031-44. doi: 10.1021/jm401557w. Epub 2013 Nov 15. J Med Chem. 2013. PMID: 24171493
Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor.
Hofmann B, Rödl CB, Kahnt AS, Maier TJ, Michel AA, Hoffmann M, Rau O, Awwad K, Pellowska M, Wurglics M, Wacker M, Zivković A, Fleming I, Schubert-Zsilavecz M, Stark H, Schneider G, Steinhilber D. Hofmann B, et al. Among authors: schneider g. Br J Pharmacol. 2012 Apr;165(7):2304-13. doi: 10.1111/j.1476-5381.2011.01707.x. Br J Pharmacol. 2012. PMID: 21955369 Free PMC article.
2,986 results