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Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.
Harding B, Lemos MC, Reed AA, Walls GV, Jeyabalan J, Bowl MR, Tateossian H, Sullivan N, Hough T, Fraser WD, Ansorge O, Cheeseman MT, Thakker RV. Harding B, et al. Among authors: lemos mc. Endocr Relat Cancer. 2009 Dec;16(4):1313-27. doi: 10.1677/ERC-09-0082. Epub 2009 Jul 20. Endocr Relat Cancer. 2009. PMID: 19620250 Free PMC article.
Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites.
Hannan FM, Nesbit MA, Zhang C, Cranston T, Curley AJ, Harding B, Fratter C, Rust N, Christie PT, Turner JJ, Lemos MC, Bowl MR, Bouillon R, Brain C, Bridges N, Burren C, Connell JM, Jung H, Marks E, McCredie D, Mughal Z, Rodda C, Tollefsen S, Brown EM, Yang JJ, Thakker RV. Hannan FM, et al. Among authors: lemos mc. Hum Mol Genet. 2012 Jun 15;21(12):2768-78. doi: 10.1093/hmg/dds105. Epub 2012 Mar 14. Hum Mol Genet. 2012. PMID: 22422767
MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas.
Walls GV, Lemos MC, Javid M, Bazan-Peregrino M, Jeyabalan J, Reed AA, Harding B, Tyler DJ, Stuckey DJ, Piret S, Christie PT, Ansorge O, Clarke K, Seymour L, Thakker RV. Walls GV, et al. Among authors: lemos mc. Cancer Res. 2012 Oct 1;72(19):5060-8. doi: 10.1158/0008-5472.CAN-12-1821. Epub 2012 Aug 21. Cancer Res. 2012. PMID: 22915754 Free PMC article.
106 results