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Evidence that the multiflorine-derived substituted quinazolidine 55P0251 augments insulin secretion and lowers blood glucose via antagonism at α2 -adrenoceptors in mice.
Lehner Z, Stadlbauer K, Brunmair B, Adorjan I, Genov M, Kautzky-Willer A, Scherer T, Scheinin M, Bauer L, Fürnsinn C. Lehner Z, et al. Among authors: stadlbauer k. Diabetes Obes Metab. 2020 Mar;22(3):290-302. doi: 10.1111/dom.13895. Epub 2019 Nov 7. Diabetes Obes Metab. 2020. PMID: 31608542 Free PMC article.
Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?
Lehner Z, Stadlbauer K, Adorjan I, Rustenbeck I, Belz M, Fenzl A, de Cillia VA, Gruber D, Bauer L, Frobel K, Brunmair B, Luger A, Fürnsinn C. Lehner Z, et al. Among authors: stadlbauer k. Diabetologia. 2012 Nov;55(11):3071-82. doi: 10.1007/s00125-012-2679-x. Epub 2012 Aug 18. Diabetologia. 2012. PMID: 22898767
78 results