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Page 1
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
Zarrinkar PP, Gunawardane RN, Cramer MD, Gardner MF, Brigham D, Belli B, Karaman MW, Pratz KW, Pallares G, Chao Q, Sprankle KG, Patel HK, Levis M, Armstrong RC, James J, Bhagwat SS. Zarrinkar PP, et al. Among authors: patel hk. Blood. 2009 Oct 1;114(14):2984-92. doi: 10.1182/blood-2009-05-222034. Epub 2009 Aug 4. Blood. 2009. PMID: 19654408 Free PMC article.
Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors.
Patel HK, Grotzfeld RM, Lai AG, Mehta SA, Milanov ZV, Chao Q, Sprankle KG, Carter TA, Velasco AM, Fabian MA, James J, Treiber DK, Lockhart DJ, Zarrinkar PP, Bhagwat SS. Patel HK, et al. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5182-5. doi: 10.1016/j.bmcl.2009.07.024. Epub 2009 Jul 9. Bioorg Med Chem Lett. 2009. PMID: 19646870
Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor.
Chao Q, Sprankle KG, Grotzfeld RM, Lai AG, Carter TA, Velasco AM, Gunawardane RN, Cramer MD, Gardner MF, James J, Zarrinkar PP, Patel HK, Bhagwat SS. Chao Q, et al. Among authors: patel hk. J Med Chem. 2009 Dec 10;52(23):7808-16. doi: 10.1021/jm9007533. J Med Chem. 2009. PMID: 19754199
A quantitative analysis of kinase inhibitor selectivity.
Karaman MW, Herrgard S, Treiber DK, Gallant P, Atteridge CE, Campbell BT, Chan KW, Ciceri P, Davis MI, Edeen PT, Faraoni R, Floyd M, Hunt JP, Lockhart DJ, Milanov ZV, Morrison MJ, Pallares G, Patel HK, Pritchard S, Wodicka LM, Zarrinkar PP. Karaman MW, et al. Among authors: patel hk. Nat Biotechnol. 2008 Jan;26(1):127-32. doi: 10.1038/nbt1358. Nat Biotechnol. 2008. PMID: 18183025
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.
Carter TA, Wodicka LM, Shah NP, Velasco AM, Fabian MA, Treiber DK, Milanov ZV, Atteridge CE, Biggs WH 3rd, Edeen PT, Floyd M, Ford JM, Grotzfeld RM, Herrgard S, Insko DE, Mehta SA, Patel HK, Pao W, Sawyers CL, Varmus H, Zarrinkar PP, Lockhart DJ. Carter TA, et al. Among authors: patel hk. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11011-6. doi: 10.1073/pnas.0504952102. Epub 2005 Jul 26. Proc Natl Acad Sci U S A. 2005. PMID: 16046538 Free PMC article.
A small molecule-kinase interaction map for clinical kinase inhibitors.
Fabian MA, Biggs WH 3rd, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, Ford JM, Galvin M, Gerlach JL, Grotzfeld RM, Herrgard S, Insko DE, Insko MA, Lai AG, Lélias JM, Mehta SA, Milanov ZV, Velasco AM, Wodicka LM, Patel HK, Zarrinkar PP, Lockhart DJ. Fabian MA, et al. Among authors: patel hk. Nat Biotechnol. 2005 Mar;23(3):329-36. doi: 10.1038/nbt1068. Epub 2005 Feb 13. Nat Biotechnol. 2005. PMID: 15711537 Free article.
People Who Self-Reported Testing HIV-Positive but Tested HIV-Negative: A Multi-Country Puzzle of Data, Serology, and Ethics, 2015-2021.
Metz M, Among VH, Dzinamarira T, Ussery F, Nkurunziza P, Bahizi J, Biraro S, Ogollah FM, Musinguzi J, Kirungi W, Naluguza M, Mwangi C, Birhanu S, Nelson LJ, Longwe H, Winterhalter FS, Voetsch AC, Parekh BS, Patel HK, Duong YT, Bray R, Farley SM. Metz M, et al. Among authors: patel hk. Trop Med Infect Dis. 2024 Sep 19;9(9):220. doi: 10.3390/tropicalmed9090220. Trop Med Infect Dis. 2024. PMID: 39330909 Free PMC article.
177 results