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Hemoglobin vesicles, polyethylene glycol (PEG)ylated liposomes developed as a red blood cell substitute, do not induce the accelerated blood clearance phenomenon in mice.
Taguchi K, Urata Y, Anraku M, Watanabe H, Kadowaki D, Sakai H, Horinouchi H, Kobayashi K, Tsuchida E, Maruyama T, Otagiri M. Taguchi K, et al. Among authors: tsuchida e. Drug Metab Dispos. 2009 Nov;37(11):2197-203. doi: 10.1124/dmd.109.028852. Epub 2009 Aug 13. Drug Metab Dispos. 2009. PMID: 19679674
Hemoglobin-vesicles as a transfusion alternative.
Tsuchida E, Sakai H, Horinouchi H, Kobayashi K. Tsuchida E, et al. Artif Cells Blood Substit Immobil Biotechnol. 2006;34(6):581-8. doi: 10.1080/10731190600973907. Artif Cells Blood Substit Immobil Biotechnol. 2006. PMID: 17090430 Review.
Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment.
Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M. Taguchi K, et al. Among authors: tsuchida e. Toxicol Appl Pharmacol. 2010 Nov 1;248(3):234-41. doi: 10.1016/j.taap.2010.08.006. Epub 2010 Aug 13. Toxicol Appl Pharmacol. 2010. PMID: 20709091
272 results