Kittaka A - Search Results

1

Synthesis of 2alpha-substituted-14-epi-previtamin D3 and its genomic activity.

Sawada D, Katayama T, Tsukuda Y, Saito N, Takano M, Saito H, Takagi K, Ochiai E, Ishizuka S, Takenouchi K, Kittaka A. Sawada D, et al. Among authors: kittaka a. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5397-400. doi: 10.1016/j.bmcl.2009.07.112. Epub 2009 Jul 28. Bioorg Med Chem Lett. 2009. PMID: 19692243

2

Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.

Kittaka A, Kuze T, Asakura T, Ito K, Miyasaka T, Inoue J. Kittaka A, et al. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3207-10. doi: 10.1016/s0960-894x(98)00584-8. Bioorg Med Chem Lett. 1998. PMID: 9873704

3

A concise and efficient route to 2alpha-(omega-hydroxyalkoxy)-1alpha,25-dihydroxyvi tam in D3: remarkably high affinity to vitamin D receptor.

Kittaka A, Suhara Y, Takayanagi H, Fujishima T, Kurihara M, Takayama H. Kittaka A, et al. Org Lett. 2000 Aug 24;2(17):2619-22. doi: 10.1021/ol006222j. Org Lett. 2000. PMID: 10990411

4

Efficient and versatile synthesis of novel 2alpha-substituted 1alpha,25-dihydroxyvitamin D(3) analogues and their docking to vitamin D receptors.

Suhara Y, Nihei KI, Kurihara M, Kittaka A, Yamaguchi K, Fujishima T, Konno K, Miyata N, Takayama H. Suhara Y, et al. Among authors: kittaka a. J Org Chem. 2001 Dec 28;66(26):8760-71. doi: 10.1021/jo010375i. J Org Chem. 2001. PMID: 11749604

5

Synthesis and testing of 2alpha-modified 1alpha,25-dihydroxyvitamin D(3) analogues with a double side chain: marked cell differentiation activity.

Suhara Y, Kittaka A, Kishimoto S, Calverley MJ, Fujishima T, Saito N, Sugiura T, Waku K, Takayama H. Suhara Y, et al. Among authors: kittaka a. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3255-8. doi: 10.1016/s0960-894x(02)00722-9. Bioorg Med Chem Lett. 2002. PMID: 12392726

6

Design and efficient synthesis of new stable 1alpha,25-dihydroxy-19-norvitamin D3 analogues containing amide bond.

Suhara Y, Kittaka A, Ono K, Kurihara M, Fujishima T, Yoshida A, Takayama H. Suhara Y, et al. Among authors: kittaka a. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3533-6. doi: 10.1016/s0960-894x(02)00800-4. Bioorg Med Chem Lett. 2002. PMID: 12443770

7

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs.

Takayama H, Kittaka A, Fujishima T, Suhara Y. Takayama H, et al. Among authors: kittaka a. Recent Results Cancer Res. 2003;164:289-317. doi: 10.1007/978-3-642-55580-0_21. Recent Results Cancer Res. 2003. PMID: 12899530 Review.

8

Design and synthesis of potent vitamin D receptor antagonists with A-ring modifications: remarkable effects of 2alpha-methyl introduction on antagonistic activity.

Fujishima T, Kojima Y, Azumaya I, Kittaka A, Takayama H. Fujishima T, et al. Among authors: kittaka a. Bioorg Med Chem. 2003 Aug 15;11(17):3621-31. doi: 10.1016/s0968-0896(03)00371-7. Bioorg Med Chem. 2003. PMID: 12901907

9

Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators.

Fujishima T, Kittaka A, Yamaoka K, Takeyama K, Kato S, Takayama H. Fujishima T, et al. Among authors: kittaka a. Org Biomol Chem. 2003 Jun 7;1(11):1863-9. doi: 10.1039/b302017g. Org Biomol Chem. 2003. PMID: 12945766

10

Efficient synthesis of 2-modified 1alpha,25-dihydroxy-19-norvitamin D3 with Julia olefination: high potency in induction of differentiation on HL-60 cells.

Ono K, Yoshida A, Saito N, Fujishima T, Honzawa S, Suhara Y, Kishimoto S, Sugiura T, Waku K, Takayama H, Kittaka A. Ono K, et al. Among authors: kittaka a. J Org Chem. 2003 Sep 19;68(19):7407-15. doi: 10.1021/jo034787y. J Org Chem. 2003. PMID: 12968893

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