Guenther EL - Search Results

1

Impact of chronic medication de-escalation in patients with cystic fibrosis taking elexacaftor, tezacaftor, ivacaftor: A retrospective review.

Guenther EL, McCoy KS, Eisner M, Bai S, Nemastil CJ, Novak KJ, Johnson T, Stephan EM. Guenther EL, et al. J Cyst Fibros. 2024 Jan;23(1):32-37. doi: 10.1016/j.jcf.2023.03.018. Epub 2023 Apr 15. J Cyst Fibros. 2024. PMID: 37069044

2

Inhibition of synucleinopathic seeding by rationally designed inhibitors.

Sangwan S, Sahay S, Murray KA, Morgan S, Guenther EL, Jiang L, Williams CK, Vinters HV, Goedert M, Eisenberg DS. Sangwan S, et al. Among authors: guenther el. Elife. 2020 Jan 2;9:e46775. doi: 10.7554/eLife.46775. Elife. 2020. PMID: 31895037 Free PMC article.

3

Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. Guenther EL, et al. Nat Struct Mol Biol. 2019 Oct;26(10):988. doi: 10.1038/s41594-019-0316-9. Nat Struct Mol Biol. 2019. PMID: 31530939 Free PMC article.

4

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. Guenther EL, et al. Nat Struct Mol Biol. 2018 Jun;25(6):463-471. doi: 10.1038/s41594-018-0064-2. Epub 2018 May 21. Nat Struct Mol Biol. 2018. PMID: 29786080 Free PMC article.

5

Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.

Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS. Guenther EL, et al. Nat Struct Mol Biol. 2018 Apr;25(4):311-319. doi: 10.1038/s41594-018-0045-5. Epub 2018 Mar 12. Nat Struct Mol Biol. 2018. PMID: 29531287 Free PMC article.

6

Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).

Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS. Sangwan S, et al. Among authors: guenther el. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8770-8775. doi: 10.1073/pnas.1705091114. Epub 2017 Jul 31. Proc Natl Acad Sci U S A. 2017. PMID: 28760994 Free PMC article.

7

Structure of the toxic core of α-synuclein from invisible crystals.

Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. Rodriguez JA, et al. Among authors: guenther el. Nature. 2015 Sep 24;525(7570):486-90. doi: 10.1038/nature15368. Epub 2015 Sep 9. Nature. 2015. PMID: 26352473 Free PMC article.

8

Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS.

Ivanova MI, Sievers SA, Guenther EL, Johnson LM, Winkler DD, Galaleldeen A, Sawaya MR, Hart PJ, Eisenberg DS. Ivanova MI, et al. Among authors: guenther el. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):197-201. doi: 10.1073/pnas.1320786110. Epub 2013 Dec 16. Proc Natl Acad Sci U S A. 2014. PMID: 24344300 Free PMC article.

9

Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD. Cooke HA, et al. Among authors: guenther el. Biochemistry. 2009 Oct 13;48(40):9590-8. doi: 10.1021/bi901257q. Biochemistry. 2009. PMID: 19702337 Free PMC article.

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