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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.
Islam I, Brown G, Bryant J, Hrvatin P, Kochanny MJ, Phillips GB, Yuan S, Adler M, Whitlow M, Lentz D, Polokoff MA, Wu J, Shen J, Walters J, Ho E, Subramanyam B, Zhu D, Feldman RI, Arnaiz DO. Islam I, et al. Among authors: yuan s. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25. doi: 10.1016/j.bmcl.2007.05.060. Epub 2007 May 23. Bioorg Med Chem Lett. 2007. PMID: 17544272
Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis.
Islam I, Yuan S, West CW, Adler M, Bothe U, Bryant J, Chang Z, Chu K, Emayan K, Gualtieri G, Ho E, Light D, Mallari C, Morser J, Phillips G, Schaefer C, Sukovich D, Whitlow M, Chen D, Buckman BO. Islam I, et al. Among authors: yuan s. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. doi: 10.1016/j.bmcl.2018.09.001. Epub 2018 Sep 5. Bioorg Med Chem Lett. 2018. PMID: 30201291
Structures of potent selective peptide mimetics bound to carboxypeptidase B.
Adler M, Buckman B, Bryant J, Chang Z, Chu K, Emayan K, Hrvatin P, Islam I, Morser J, Sukovich D, West C, Yuan S, Whitlow M. Adler M, et al. Among authors: yuan s. Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):149-57. doi: 10.1107/S0907444907057228. Epub 2008 Jan 16. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18219114
Reversible, orally available ADP receptor (P2Y12) antagonists Part I: Hit to lead process.
Islam I, Yuan S, Wei RG, Xu W, Morrissey M, Mohan R, Zheng D, DiMella A, Dunning L, Snider M, Subramanyam B, Tseng JL, Bryant JA, Buckman BO. Islam I, et al. Among authors: yuan s. Bioorg Med Chem Lett. 2018 May 15;28(9):1459-1463. doi: 10.1016/j.bmcl.2018.03.090. Epub 2018 Mar 31. Bioorg Med Chem Lett. 2018. PMID: 29628327
Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
Feldman RI, Wu JM, Polokoff MA, Kochanny MJ, Dinter H, Zhu D, Biroc SL, Alicke B, Bryant J, Yuan S, Buckman BO, Lentz D, Ferrer M, Whitlow M, Adler M, Finster S, Chang Z, Arnaiz DO. Feldman RI, et al. Among authors: yuan s. J Biol Chem. 2005 May 20;280(20):19867-74. doi: 10.1074/jbc.M501367200. Epub 2005 Mar 16. J Biol Chem. 2005. PMID: 15772071 Free article.
8,542 results