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Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein.
Russell Lewis B, Uddin MR, Moniruzzaman M, Kuo KM, Higgins AJ, Shah LMN, Sobott F, Parks JM, Hammerschmid D, Gumbart JC, Zgurskaya HI, Reading E. Russell Lewis B, et al. Among authors: higgins aj. Nat Commun. 2023 Jul 18;14(1):3900. doi: 10.1038/s41467-023-39615-x. Nat Commun. 2023. PMID: 37463890 Free PMC article.
The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding.
White P, Haysom SF, Iadanza MG, Higgins AJ, Machin JM, Whitehouse JM, Horne JE, Schiffrin B, Carpenter-Platt C, Calabrese AN, Storek KM, Rutherford ST, Brockwell DJ, Ranson NA, Radford SE. White P, et al. Among authors: higgins aj. Nat Commun. 2021 Jul 7;12(1):4174. doi: 10.1038/s41467-021-24432-x. Nat Commun. 2021. PMID: 34234105 Free PMC article.
The Animal Health Trust (1942-2020).
Higgins AJ, Meldrum KC, Johnson JB, Biggs PM, Chandler EA. Higgins AJ, et al. Vet J. 2021 Jun;272:105681. doi: 10.1016/j.tvjl.2021.105681. Epub 2021 Apr 19. Vet J. 2021. PMID: 33895064 Review. No abstract available.
Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs.
Iadanza MG, Schiffrin B, White P, Watson MA, Horne JE, Higgins AJ, Calabrese AN, Brockwell DJ, Tuma R, Kalli AC, Radford SE, Ranson NA. Iadanza MG, et al. Among authors: higgins aj. Commun Biol. 2020 Dec 14;3(1):766. doi: 10.1038/s42003-020-01419-w. Commun Biol. 2020. PMID: 33318620 Free PMC article.
Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes.
Cannon CP, Pratley R, Dagogo-Jack S, Mancuso J, Huyck S, Masiukiewicz U, Charbonnel B, Frederich R, Gallo S, Cosentino F, Shih WJ, Gantz I, Terra SG, Cherney DZI, McGuire DK; VERTIS CV Investigators. Cannon CP, et al. N Engl J Med. 2020 Oct 8;383(15):1425-1435. doi: 10.1056/NEJMoa2004967. Epub 2020 Sep 23. N Engl J Med. 2020. PMID: 32966714 Clinical Trial.
112 results