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Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice.
Kerley-Hamilton JS, Trask HW, Ridley CJ, Dufour E, Lesseur C, Ringelberg CS, Moodie KL, Shipman SL, Korc M, Gui J, Shworak NW, Tomlinson CR. Kerley-Hamilton JS, et al. Among authors: trask hw. Toxicol Sci. 2012 Apr;126(2):391-404. doi: 10.1093/toxsci/kfs002. Epub 2012 Jan 6. Toxicol Sci. 2012. PMID: 22228805 Free PMC article.
Obesity is mediated by differential aryl hydrocarbon receptor signaling in mice fed a Western diet.
Kerley-Hamilton JS, Trask HW, Ridley CJ, Dufour E, Ringelberg CS, Nurinova N, Wong D, Moodie KL, Shipman SL, Moore JH, Korc M, Shworak NW, Tomlinson CR. Kerley-Hamilton JS, et al. Among authors: trask hw. Environ Health Perspect. 2012 Sep;120(9):1252-9. doi: 10.1289/ehp.1205003. Epub 2012 May 18. Environ Health Perspect. 2012. PMID: 22609946 Free PMC article.
SMAD4-dependent polysome RNA recruitment in human pancreatic cancer cells.
Thornley JA, Trask HW, Ringelberg CS, Ridley CJ, Wang S, Sal-Lari RC, Moore JH, Korc M, Tomlinson CR. Thornley JA, et al. Among authors: trask hw. Mol Carcinog. 2012 Oct;51(10):771-82. doi: 10.1002/mc.20845. Epub 2011 Aug 30. Mol Carcinog. 2012. PMID: 22965423 Free PMC article.
Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1.
Moyer BJ, Rojas IY, Kerley-Hamilton JS, Hazlett HF, Nemani KV, Trask HW, West RJ, Lupien LE, Collins AJ, Ringelberg CS, Gimi B, Kinlaw WB 3rd, Tomlinson CR. Moyer BJ, et al. Among authors: trask hw. Toxicol Appl Pharmacol. 2016 Jun 1;300:13-24. doi: 10.1016/j.taap.2016.03.011. Epub 2016 Mar 25. Toxicol Appl Pharmacol. 2016. PMID: 27020609 Free PMC article.
Plasma DNA as a "liquid biopsy" incompletely complements tumor biopsy for identification of mutations in a case series of four patients with oligometastatic breast cancer.
Chamberlin MD, Wells JD, Shee K, Bean JR, Marotti JD, Wells WA, Trask HW, Kolling FW, Bhatt A, Kaufman PA, Schwartz GN, Gemery JM, McNulty NJ, Tsapakos MJ, Barth RJ, Arrick BA, Gui J, Miller TW. Chamberlin MD, et al. Among authors: trask hw. Breast Cancer Res Treat. 2020 Aug;182(3):665-677. doi: 10.1007/s10549-020-05714-2. Epub 2020 Jun 19. Breast Cancer Res Treat. 2020. PMID: 32562118 Free PMC article.
Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.
Noreault TL, Kostrubsky VE, Wood SG, Nichols RC, Strom SC, Trask HW, Wrighton SA, Evans RM, Jacobs JM, Sinclair PR, Sinclair JF. Noreault TL, et al. Among authors: trask hw. Drug Metab Dispos. 2005 Jul;33(7):993-1003. doi: 10.1124/dmd.105.003954. Epub 2005 Apr 15. Drug Metab Dispos. 2005. PMID: 15833926
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