Luxen A - Search Results

1

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

Inglis SR, Zervosen A, Woon EC, Gerards T, Teller N, Fischer DS, Luxen A, Schofield CJ. Inglis SR, et al. Among authors: luxen a. J Med Chem. 2009 Oct 8;52(19):6097-106. doi: 10.1021/jm9009718. J Med Chem. 2009. PMID: 19731939

2

Structure guided development of potent reversibly binding penicillin binding protein inhibitors.

Woon EC, Zervosen A, Sauvage E, Simmons KJ, Zivec M, Inglis SR, Fishwick CW, Gobec S, Charlier P, Luxen A, Schofield CJ. Woon EC, et al. Among authors: luxen a. ACS Med Chem Lett. 2011 Jan 11;2(3):219-23. doi: 10.1021/ml100260x. eCollection 2011 Mar 10. ACS Med Chem Lett. 2011. PMID: 24900305 Free PMC article.

3

Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C.

Zervosen A, Bouillez A, Herman A, Amoroso A, Joris B, Sauvage E, Charlier P, Luxen A. Zervosen A, et al. Among authors: luxen a. Bioorg Med Chem. 2012 Jun 15;20(12):3915-24. doi: 10.1016/j.bmc.2012.04.018. Epub 2012 Apr 16. Bioorg Med Chem. 2012. PMID: 22579615 Free article.

4

Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening.

Miguet L, Zervosen A, Gerards T, Pasha FA, Luxen A, Distèche-Nguyen M, Thomas A. Miguet L, et al. Among authors: luxen a. J Med Chem. 2009 Oct 8;52(19):5926-36. doi: 10.1021/jm900625q. J Med Chem. 2009. PMID: 19746934

5

Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA).

Contreras-Martel C, Amoroso A, Woon EC, Zervosen A, Inglis S, Martins A, Verlaine O, Rydzik AM, Job V, Luxen A, Joris B, Schofield CJ, Dessen A. Contreras-Martel C, et al. Among authors: luxen a. ACS Chem Biol. 2011 Sep 16;6(9):943-51. doi: 10.1021/cb2001846. Epub 2011 Aug 3. ACS Chem Biol. 2011. PMID: 21732689

6

Stereoselective synthesis of lanthionine derivatives in aqueous solution and their incorporation into the peptidoglycan of Escherichia coli.

Denoël T, Zervosen A, Gerards T, Lemaire C, Joris B, Blanot D, Luxen A. Denoël T, et al. Among authors: luxen a. Bioorg Med Chem. 2014 Sep 1;22(17):4621-8. doi: 10.1016/j.bmc.2014.07.023. Epub 2014 Jul 23. Bioorg Med Chem. 2014. PMID: 25124861

7

Synthesis and biological evaluation of potential threonine synthase inhibitors: Rhizocticin A and Plumbemycin A.

Gahungu M, Arguelles-Arias A, Fickers P, Zervosen A, Joris B, Damblon C, Luxen A. Gahungu M, et al. Among authors: luxen a. Bioorg Med Chem. 2013 Sep 1;21(17):4958-67. doi: 10.1016/j.bmc.2013.06.064. Epub 2013 Jul 8. Bioorg Med Chem. 2013. PMID: 23891162

8

1,6-AnhMurNAc derivatives for assay development of amidase AmiD.

Mercier F, Zervosen A, Teller N, Frère JM, Herman R, Pennartz A, Joris B, Luxen A. Mercier F, et al. Among authors: luxen a. Bioorg Med Chem. 2010 Nov 1;18(21):7422-31. doi: 10.1016/j.bmc.2010.09.010. Epub 2010 Sep 8. Bioorg Med Chem. 2010. PMID: 20889346

9

Development of new drugs for an old target: the penicillin binding proteins.

Zervosen A, Sauvage E, Frère JM, Charlier P, Luxen A. Zervosen A, et al. Among authors: luxen a. Molecules. 2012 Oct 24;17(11):12478-505. doi: 10.3390/molecules171112478. Molecules. 2012. PMID: 23095893 Free PMC article. Review.

10

Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins.

Macheboeuf P, Fischer DS, Brown T Jr, Zervosen A, Luxen A, Joris B, Dessen A, Schofield CJ. Macheboeuf P, et al. Among authors: luxen a. Nat Chem Biol. 2007 Sep;3(9):565-9. doi: 10.1038/nchembio.2007.21. Epub 2007 Aug 5. Nat Chem Biol. 2007. PMID: 17676039

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