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Pancreatic cancer cells overexpressing interleukin 6 induce T-cell-mediated tumor clearance and durable anti-tumor immune response.
Arneson-Wissink PC, Bartlett AQ, Mendez H, Zhu X, Dickie J, McWhorter M, Levasseur PR, Diba P, Byrne KT, Scott GD, Eil R, Grossberg AJ. Arneson-Wissink PC, et al. Among authors: byrne kt. bioRxiv [Preprint]. 2024 Sep 27:2024.09.26.615308. doi: 10.1101/2024.09.26.615308. bioRxiv. 2024. PMID: 39386578 Free PMC article. Preprint.
Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer.
Blise KE, Sivagnanam S, Betts CB, Betre K, Kirchberger N, Tate BJ, Furth EE, Dias Costa A, Nowak JA, Wolpin BM, Vonderheide RH, Goecks J, Coussens LM, Byrne KT. Blise KE, et al. Among authors: byrne kt. Cancer Immunol Res. 2024 May 2;12(5):544-558. doi: 10.1158/2326-6066.CIR-23-0873. Cancer Immunol Res. 2024. PMID: 38381401 Free PMC article.
Machine learning links T cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer.
Blise KE, Sivagnanam S, Betts CB, Betre K, Kirchberger N, Tate B, Furth EE, Dias Costa A, Nowak JA, Wolpin BM, Vonderheide RH, Goecks J, Coussens LM, Byrne KT. Blise KE, et al. Among authors: byrne kt. bioRxiv [Preprint]. 2023 Oct 23:2023.10.20.563335. doi: 10.1101/2023.10.20.563335. bioRxiv. 2023. Update in: Cancer Immunol Res. 2024 May 2;12(5):544-558. doi: 10.1158/2326-6066.CIR-23-0873 PMID: 37961410 Free PMC article. Updated. Preprint.
An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequences.
Gurun B, Horton W, Murugan D, Zhu B, Leyshock P, Kumar S, Byrne KT, Vonderheide RH, Margolin AA, Mori M, Spellman PT, Coussens LM, Speed TP. Gurun B, et al. Among authors: byrne kt. Res Sq [Preprint]. 2023 Feb 16:rs.3.rs-2140339. doi: 10.21203/rs.3.rs-2140339/v1. Res Sq. 2023. Update in: BMC Genomics. 2023 Jun 26;24(1):349. doi: 10.1186/s12864-023-09424-z PMID: 36824803 Free PMC article. Updated. Preprint.
Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial.
Padrón LJ, Maurer DM, O'Hara MH, O'Reilly EM, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Yu JX, Pfeiffer SM, Spasic M, Xu J, Gherardini PF, Karakunnel J, Mick R, Alanio C, Byrne KT, Hollmann TJ, Moore JS, Jones DD, Tognetti M, Chen RO, Yang X, Salvador L, Wherry EJ, Dugan U, O'Donnell-Tormey J, Butterfield LH, Hubbard-Lucey VM, Ibrahim R, Fairchild J, Bucktrout S, LaVallee TM, Vonderheide RH. Padrón LJ, et al. Among authors: byrne kt. Nat Med. 2022 Jun;28(6):1167-1177. doi: 10.1038/s41591-022-01829-9. Epub 2022 Jun 3. Nat Med. 2022. PMID: 35662283 Free PMC article. Clinical Trial.
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