Guy RK - Search Results

1

Structure-guided development of selective TbcatB inhibitors.

Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Mallari JP, et al. Among authors: guy rk. J Med Chem. 2009 Oct 22;52(20):6489-93. doi: 10.1021/jm900908p. J Med Chem. 2009. PMID: 19769357 Free PMC article.

2

Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

Yang H, Shelat AA, Guy RK, Gopinath VS, Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS. Yang H, et al. Among authors: guy rk. J Biol Chem. 2003 Sep 12;278(37):35079-85. doi: 10.1074/jbc.M303098200. Epub 2003 Jun 27. J Biol Chem. 2003. PMID: 12832418 Free article.

3

Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain.

Springsteel MF, Galietta LJ, Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. Springsteel MF, et al. Among authors: guy rk. Bioorg Med Chem. 2003 Sep 1;11(18):4113-20. doi: 10.1016/s0968-0896(03)00435-8. Bioorg Med Chem. 2003. PMID: 12927873

4

A novel protein crosslinking reagent for the determination of moderate resolution protein structures by mass spectrometry (MS3-D).

Fujii N, Jacobsen RB, Wood NL, Schoeniger JS, Guy RK. Fujii N, et al. Among authors: guy rk. Bioorg Med Chem Lett. 2004 Jan 19;14(2):427-9. doi: 10.1016/j.bmcl.2003.10.043. Bioorg Med Chem Lett. 2004. PMID: 14698174

5

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.

Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Among authors: guy rk. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423

6

A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin.

Anderson MO, Shelat AA, Guy RK. Anderson MO, et al. Among authors: guy rk. J Org Chem. 2005 Jun 10;70(12):4578-84. doi: 10.1021/jo0503153. J Org Chem. 2005. PMID: 15932292

7

Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators.

Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. Arnold LA, et al. Among authors: guy rk. J Biol Chem. 2005 Dec 30;280(52):43048-55. doi: 10.1074/jbc.M506693200. Epub 2005 Oct 31. J Biol Chem. 2005. PMID: 16263725 Free article.

8

A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding.

Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. Arnold LA, et al. Among authors: guy rk. Sci STKE. 2006 Jun 27;2006(341):pl3. doi: 10.1126/stke.3412006pl3. Sci STKE. 2006. PMID: 16804159

9

Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum.

Madrid PB, Liou AP, DeRisi JL, Guy RK. Madrid PB, et al. Among authors: guy rk. J Med Chem. 2006 Jul 27;49(15):4535-43. doi: 10.1021/jm0600951. J Med Chem. 2006. PMID: 16854059 Free PMC article.

10

Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.

May BC, Witkop J, Sherrill J, Anderson MO, Madrid PB, Zorn JA, Prusiner SB, Cohen FE, Guy RK. May BC, et al. Among authors: guy rk. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4913-6. doi: 10.1016/j.bmcl.2006.06.050. Epub 2006 Jul 24. Bioorg Med Chem Lett. 2006. PMID: 16860557

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